生物节律紊乱与青少年心血管代谢风险关联及其机制的研究进展

Research progress on the association between biorhythm disorders and cardiovascular metabolic risk in adolescents and possible mechanisms

青少年处于由儿童向成人角色转变的重要过渡时期,该时期青少年的行为习惯和生理周期变化显著,生物节律易出现紊乱;同时由于青少年时期超重和肥胖率增加,心血管代谢风险显著上升。研究就生物节律紊乱、青少年心血管代谢健康的流行现状和关联以及潜在的表观遗传调控机制进行综述,为调控生物节律促进青少年心血管代谢健康提供理论依据。

Adolescence is a unique transitional period from childhood to adulthood,during which behavioral habits and physiological cycles undergo significant changes,and biorhythms are vulnerable to be disrupted.Meanwhile,due to increased rates of overweight and obesity,cardiovascular metabolic risk significantly increases during adolescence.The article reviews the prevalence,correlation,and potential epigenetic regulatory mechanisms of biorhythm disorders and adolescent cardiovascular metabolic health,providing a theoretical basis for regulating biorhythm to promote adolescent cardiovascular metabolic health.