2016年和2019年新疆维吾尔自治区博州不同人群肥胖代谢表型异质性变化分析

Analysis on the heterogeneity of obesity metabolic phenotypes among different populations in Bozhou,Xinjiang Uygur Autonomous Region in 2016 and 2019

目的 了解新疆维吾尔自治区(新疆)博州成人肥胖代谢表型异质性情况,探讨在不同性别和年龄人群中肥胖代谢表型分布变化情况,为有针对性地选择加强干预的人群提供依据。方法 收集2016年与2019年新疆博州参与全民健康体检的成年人群相关数据,根据体质量指数(body mass index,BMI)和血压、空腹血糖、三酰甘油和高密度脂蛋白胆固醇4个代谢指标,综合判定体质量和代谢情况,将研究对象分为代谢正常非肥胖(metabolically healthy non-obesity, MHNO)、代谢异常非肥胖(metabolically unhealthy non-obesity, MUNO)、代谢正常肥胖(metabolically healthy obesity, MHO)和代谢异常肥胖(metabolically unhealthy obesity,MUO)。采用配对t检验和配对χ2检验分析2016年与2019年博州不同性别和年龄人群BMI、代谢情况和肥胖代谢表型分布差异性。结果 2016年博州5 484名成人的肥胖代谢表型分布为MHNO者1 460例(26.62%),MUNO者2 690例(49.05%),MHO者282例(5.14%),MUO者1 052例(19.18%);2019年为MHNO者1 387例(25.29%), MUNO者2 702例(49.27%), MHO者288例(5.25%),MUO者1 107例(20.19%)。在不同性别中,男性2019年MUNO者与MUO者的比例高于2016年(MUNO:56.86%vs. 53.48%;MUO:20.76%vs. 20.43%;χ^(2)=13.753,P=0.033);女性2019年MHO者与MUO者的比例高于2016年(MHO:7.21%vs.6.27%;MUO:19.70%vs.18.12%;χ^(2)=25.814,P<0.01)。在不同年龄段中,18~<40岁人群2016年与2019年肥胖代谢表型分布的差异无统计学意义(χ^(2)=5.229,P=0.515);40~<60岁人群2019年MHNO者与MHO者的比例高于2016年(MHNO:38.05%vs.32.02%;MHO:8.06%vs.7.53%;χ^(2)=19.459,P=0.003);≥60岁人群2019年MUNO者与MUO者的比例高于2016年(MUNO:58.59%vs.55.43%;MUO:21.99%vs.20.01%;χ^(2)=48.949,P<0.01)。结论 新疆博州成人肥胖代谢表型较为稳定,但肥胖代谢异质性明显。不同性别和年龄人群的肥胖代谢表型随时间变化存在差异。

Objective To explore the heterogeneity of obesity metabolic phenotypes in adults in Bozhou,Xingjiang Uygur Autonomous Region,and the variation of its distribution across different sex and age groups,so as to provide evidence for choosing target population of strengthened interventions.Methods Relevant data were collected from 5484 adults who participated in the national health check-up in Bozhou,Xinjiang in 2016 and 2019.According to body mass index(BMI)and four metabolic indexes(blood pressure,fasting blood glucose,triglycerides and high-density lipoprotein cholesterol),the weight and metabolism of the participants were comprehensively assessed and the participants were thereby classified into metabolically healthy non-obesity(MHNO),metabolically unhealthy non-obesity(MUNO),metabolically healthy obesity(MHO)and metabolically unhealthy obesity(MUO)groups.Paired t-test and paired x test were used to analyze the differences in BMI,metabolic status and obesity metabolic phenotypes between 2016 and 2019 in different sex and age groups in Bozhou.ResultssThe distribution of obesity metabolic phenotypes in the 5484 adults in Bozhou in 2016 was 1460(26.62%)for MHNO,2690(49.05%)for MUNO,282(5.14%)for MHO,and 1052(19.18%)for MUO;in 2019 was 1387(25.29%)for MHNO,2702(49.27%)for MUNO,288(5.25%)for MHO,and 1107(20.19%)for MUO.By sex,the proportions of MUNO and MUO were higher in 2019 than in 2016 for men(MUNO:56.86%vs.53.48%;MUO:20.76%us.20.43%;x^(2)=13.753,P=0.033),and the proportions of MHO and MUO in 2019 were higher than those in 2016 for women(MHO:7.21%us.6.27%;MUO:19.70%vs.18.12%;x^(2)=25.814,P<0.01).As for age,the proportions of MHNO and MHO were higher in 2019 than in 2016 for those aged 40-<60 years(MHNO:38.05%us.32.02%;MHO:8.06%us.7.53%;x^(2)=19.459,P=0.003),and the proportions of MUNO and MUO were higher in 2019 than in 2016 for those aged≥60 years(MUNO:58.59%us.55.43%;MUO:21.99%vs.20.01%;x^(2)=48.949,P<0.01).Conclusions The overall distribution of obesity metabolic phenotypes in adults in Bozhou may be generally stable,but with obvious heterogeneity.There are differences in the distribution of obesity metabolic phenotypes over time among different sex and age groups.