生物可降解聚酯/生物陶瓷3D打印骨组织工程支架研究进展

Research advances in 3D printed bone tissue engineering scaffolds based on biodegradable polyester/bioceramics

移植骨植入物是目前治疗骨缺损的公认有效手段之一。生物可降解聚酯/生物陶瓷复合材料结合了生物可降解聚酯的良好力学性能、可降解性能和生物陶瓷的成骨活性,为骨植入物材料提供了新的选择。骨组织工程通过模拟骨骼微环境,加速骨缺损修复。将生物可降解聚酯/生物陶瓷复合材料制备成骨组织工程支架,能进一步加快骨修复进程。3D打印技术的引入能使生物可降解聚酯/生物陶瓷骨组织工程支架的制备过程精确、可重复且具备高自由度,展现出了良好的发展前景。本文阐述了骨组织工程支架应具备的各项性能,总结了近年来国内外学者对生物可降解聚酯/生物陶瓷骨组织工程支架上述性能的改善策略,并展望未来该研究领域的发展方向。

Transplantation of bone implants is currently recognized as one of the effective means treating bone defects.Biodegradable polyester/bioceramics composites combine good mechanical and degradable properties of biodegradable polyester with the osteogenic activity of bioceramics,thereby providing a new alternative for bone implant materials.Bone tissue engineering accelerates bone defect repair by simulating the bone microenvironment.The fabrication of biodegradable polyester/bioceramics composites into bone tissue engineering scaffolds can further accelerate the process of bone repair,and the introduction of 3D printing technology enables the preparation of biodegradable polyester/bioceramics bone tissue engineering scaffolds more precise,reproducible,and flexible,which exhibits very promising development.This review presents physical properties of bone tissue engineering scaffolds,summarizes the strategies from domestic and foreign scholars to improve the performance of bone tissue engineering scaffolds based on biodegradable polyester/bioceramics composite in recent years.Besides,the future development perspectives in this field are proposed in the field of research.