头痛合剂治疗紧张型头痛伴焦虑患者的临床疗效分析

Analysis of the clinical efficacy of headache mixture in patients with tension type headache and anxiety

目的探讨紧张型头痛(TTH)伴焦虑患者采取头痛合剂治疗的临床疗效。方法选择100例TTH伴焦虑患者,以双色球法分为对照组与观察组,每组50例。对照组实施常规西医治疗,观察组实施常规西医治疗联合头痛合剂治疗。比较两组中医证候积分、临床疗效、负面心理情绪、生化指标[同型半胱氨酸(Hcy)、纤维蛋白原、血浆粘度、全血粘度]、头痛频率与持续时间。结果与对照组总有效率比较观察组更高,差异显著(94.00%VS 78.00%,P<0.05)。治疗后,观察组Hcy(10.85±2.95)μmol/L、纤维蛋白原(2.41±0.32)g/L、全血粘度(9.11±2.36)mPa·s、血浆粘度(1.15±0.38)mPa·s均低于对照组的(12.12±3.05)μmol/L、(3.05±0.48)g/L、(10.59±2.75)mPa·s、(1.45±0.42)mPa·s,差异显著(P<0.05)。治疗后,观察组头痛、昏蒙、面色苍白、胸胁满闷、纳呆呕恶积分分别为(0.92±0.22)、(0.82±0.15)、(0.78±0.18)、(0.85±0.21)、(0.89±0.24)分,低于对照组的(1.25±0.26)、(1.18±0.22)、(1.16±0.20)、(1.23±0.25)、(1.24±0.28)分,差异显著(P<0.05)。治疗后,观察组头痛频率低于对照组,头痛持续时间短于对照组,差异显著(P<0.05)。治疗后,观察组焦虑评分、抑郁评分低于对照组,差异显著(P<0.05)。结论TTH伴焦虑患者予以常规西医基础上联合头痛合剂治疗,能更好地缓解患者的焦虑情绪,并更好地减轻患者的头痛症状,有利于生化指标的改善,从而全面提升临床效果,值得临床应用。

Objective To explore the clinical efficacy of headache mixture in patients with tension type headache(TTH)and anxiety.Methods 100 patients with TTH and anxiety were selected and divided into a control group and an observation group by double chromosphere method,each with 50 cases.The control group was treated with conventional western treatment,and the observation group was treated with conventional western treatment and headache mixture.The traditional Chinese medicine syndrome score,clinical efficacy,negative psychological emotion,biochemical indexes[homocysteine(Hcy),fibrinogen,plasma viscosity,whole blood viscosity],frequency and duration of headache were compared.Results The total effective rate in the observation group was significantly higher than that in the control group;the difference was significant(94.00%VS 78.00%,P<0.05).After treatment,the observation group had Hcy of(10.85±2.95)μmol/L,fibrinogen of(2.41±0.32)g/L,whole blood viscosity of(9.11±2.36)mPa·s and plasma viscosity of(1.15±0.38)mPa·s,which were lower than(12.12±3.05)μmol/L,(3.05±0.48)g/L,(10.59±2.75)mPa·s and(1.45±0.42)mPa·s in the control group.The difference was significant(P<0.05).After treatment,the scores of headache,dizziness,pale face,chest fullness and nausea and retching were(0.92±0.22),(0.82±0.15),(0.78±0.18),(0.85±0.21)and(0.89±0.24)points in the observation group,which were lower than(1.25±0.26),(1.18±0.22),(1.16±0.20),(1.23±0.25)and(1.24±0.28)points in the control group.The difference was significant(P<0.05).After treatment,the observation group had lower frequency of headache than that in the control group,and shorter duration of headache than that in the control group(P<0.05).After treatment,the anxiety score and depression score of the observation group were lower than the control group.The difference was significant(P<0.05).Conclusion For patients with TTH and anxiety,headache mixture based on conventional western medicine can better relieve the anxiety of patients,and better reduce the headache symptoms of patients,which is conducive to the improvement of biochemical indicators,so as to comprehensively improve the clinical effect.It is worthy of clinical application.