阿托伐他汀治疗进展性脑卒中的临床效果分析

Clinical effect analysis of atorvastatin in the treatment of progressive stroke

目的探讨阿托伐他汀治疗进展性脑卒中的临床效果。方法96例进展性脑卒中患者,随机分为对照组和观察组,每组48例。对照组使用常规治疗,观察组在对照组基础上使用阿托伐他汀治疗。比较两组临床疗效、美国国立卫生研究院卒中量表(NIHSS)评分和巴氏指数(BI)、血脂指标、血液流变学指标。结果观察组治疗总有效率为95.83%,明显高于对照组的77.08%(P<0.05)。治疗后,相对于对照组的(14.27±3.62)、(60.94±9.27)分,观察组NIHSS评分(10.15±2.87)分更低,而BI(73.51±8.35)分显著更高(P<0.05)。治疗后,观察组总胆固醇(TC)(4.45±0.61)mmol/L、甘油三酯(TG)(1.31±0.22)mmol/L、低密度脂蛋白胆固醇(LDL-C)(2.78±0.35)mmol/L较对照组的(5.22±0.68)、(1.57±0.25)、(3.68±0.47)mmol/L更低,而高密度脂蛋白胆固醇(HDL-C)(1.32±0.20)mmol/L则较对照组的(1.04±0.21)mmol/L更高(P<0.05)。治疗后,观察组血浆粘度(1.40±0.29)mPa·s、红细胞压积(36.89±3.37)%、全血高切粘度(4.70±1.03)mPa·s、全血低切粘度(9.78±2.25)mPa·s均较对照组的(1.76±0.31)mPa·s、(44.68±4.09)%、(5.26±1.09)mPa·s、(11.32±2.40)mPa·s更低(P<0.05)。结论阿托伐他汀治疗进展性脑卒中的临床效果显著,能有效降低血脂及血液粘稠度,促进受损神经功能的修复,改善日常生活能力。

Objective To explore the clinical effect of atorvastatin in the treatment of progressive stroke.Methods 96 patients with progressive stroke were randomly divided into a control group and an observation group,with 48 cases in each group.The control group was treated with routine therapy,and the observation group was treated with atorvastatin.The clinical efficacy,National Institute Health Stroke scale(NIHSS)score,Barthel index(BI),blood lipid index and hemorheology index were compared.Results The total effective rate of the observation group was 95.83%,which was significantly higher than 77.08%of the control group(P<0.05).After treatment,the observation group had lower NIHSS score of(10.15±2.87)points than(14.27±3.62)points in the control group,and higher BI score of(73.51±8.35)points than(60.94±9.27)points in the control group(P<0.05).After treatment,the observation group had total cholesterol(TC)of(4.45±0.61)mmol/L,triglycerides(TG)of(1.31±0.22)mmol/L,and low-density lipoprotein cholesterol(LDL-C)of(2.78±0.35)mmol/L,which were lower than(5.22±0.68),(1.57±0.25),and(3.68±0.47)mmol/L in the control group;while the observation group had higher high-density lipoprotein cholesterol(HDL-C)of(1.32±0.20)mmol/L than(1.04±0.21)mmol/L in the control group(P<0.05).After treatment,the observation group had plasma viscosity of(1.40±0.29)mPa·s,hematocrit of(36.89±3.37)%,whole blood high shear viscosity of(4.70±1.03)mPa·s,and whole blood low shear viscosity of(9.78±2.25)mPa·s,which were lower than(1.76±0.31)mPa·s,(44.68±4.09)%,(5.26±1.09)mPa·s,and(11.32±2.40)mPa·s in the control group(P<0.05).Conclusion Atorvastatin has a significant clinical effect on progressive stroke,which can effectively reduce blood lipid and blood viscosity,promote the repair of damaged neurological function and improve the ability of daily living.