小儿肺炎应用阿奇霉素治疗的效果分析

Analysis of the effect of azithromycin in the treatment of pediatric pneumonia

目的分析小儿肺炎应用阿奇霉素治疗的效果。方法120例肺炎患儿作为研究对象,随机分为对照组和实验组,每组60例。对照组采用红霉素治疗,实验组采用阿奇霉素治疗。对比两组临床疗效、炎性因子[肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平、肺功能指标[呼气流速峰值(PEF)、第1秒用力呼气容积(FEV1)、第1秒用力呼气容积与用力肺活量的比值(FEV1/FVC)]、不良反应发生率。结果实验组治疗总有效率96.67%高于对照组的86.67%(P<0.05)。治疗后,实验组TNF-α(1.31±0.28)ng/ml、CRP(7.09±1.22)mg/L、IL-6(62.25±5.18)pg/ml均低于对照组的(2.26±0.30)ng/ml、(9.24±1.50)mg/L、(100.85±7.34)pg/ml(P<0.05)。治疗后,实验组PEF(4.05±0.58)L/s、FEV1(3.00±0.82)L、FEV1/FVC(80.55±5.38)%均高于对照组的(3.56±0.49)L/s、(2.05±0.46)L、(73.85±4.14)%(P<0.05)。实验组不良反应发生率5.00%低于对照组的16.67%(P<0.05)。结论阿奇霉素的应用能够有效缓解肺炎患儿的临床症状,改善患儿的肺功能,降低患儿机体炎性因子水平,对提高患儿的治疗效果,降低不良反应的发生率有非常重要的作用。

Objective To analyze the effect of azithromycin in the treatment of pediatric pneumonia.Methods 120 children with pneumonia were selected as the study subjects,and the above children were randomly divided into a control group and an experimental group,with 60 cases in each group.The control group was treated with erythromycin,and the experimental group was treated with azithromycin.The clinical efficacy,inflammatory factors[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6)],pulmonary function indicators[peak expiratory flow rate(PEF),forced expiratory volume in one second(FEV1),ratio of FEV1 to forced vital capacity(FEV1/FVC)]and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the experimental group was 96.67%,which was higher than the control group's 86.67%(P<0.05).After treatment,the experimental group had TNF-αof(1.31±0.28)ng/ml,CRP of(7.09±1.22)mg/L,and IL-6 of(62.25±5.18)pg/ml,which were lower than(2.26±0.30)ng/ml,(9.24±1.50)mg/L,and(100.85±7.34)pg/ml in the control group(P<0.05).After treatment,the experimental group had PEF of(4.05±0.58)L/s,FEV1 of(3.00±0.82)L,and FEV1/FVC of(80.55±5.38)%,which were higher than(3.56±0.49)L/s,(2.05±0.46)L,and(73.85±4.14)%in the control group(P<0.05).The incidence of adverse reactions in the experimental group was 5.00%,which was lower than the control group's 16.67%(P<0.05).Conclusion The application of azithromycin can effectively alleviate the clinical symptoms of children with pneumonia,improve their lung function,reduce the level of inflammatory factors,and play a very important role in improving the therapeutic effect of children and reducing the incidence of adverse reactions.