CO_(2)点阵激光预处理后光动力疗法在面部扁平疣患者中的应用研究

Application of CO_(2) Fractional Laser Pretreatment Combined with Photodynamic Therapy in Patients with Facial Flat Warts

目的:观察CO_(2)点阵激光预处理后光动力疗法在面部扁平疣患者中的应用效果。方法:选取2020年5月至2023年3月于我院就诊的109例面部扁平疣患者,采用随机数字表法进行简单随机分组分为对照组55例(剔除2例,最终完成53例)和观察组54例(剔除1例,最终完成53例)。对照组仅给予光动力疗法治疗,观察组在CO_(2)点阵激光预处理后给予光动力疗法治疗。比较两组总有效率和随访6个月后的复发率。观察两组治疗前后炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(INF-γ)]、皮损症状评分的差异。结果:观察组整体疗效高于对照组(P<0.05)。治疗前两组炎症因子比较无差异(P>0.05)。两组治疗后炎症因子较前下降,观察组炎症因子治疗前后差值大于对照组(P<0.05)。治疗前两组皮损症状评分比较无差异。两组治疗后皮损数量、大小、颜色、厚度及瘙痒程度及同形反应评分较前下降,观察组皮损症状评分治疗前后差值大于对照组(P<0.05)。随访6个月,观察组复发率为3.701%(1例/27例)与对照组的25.00%(4例/16例)比较,差异无统计学意义(P>0.05)。结论:CO_(2)点阵激光预处理后光动力疗法可减轻面部扁平疣患者炎症反应,减轻症状,提高疗效。

Objective:To investigate the efficacy of CO_(2) fractional laser pretreatment combined with photodynamic therapy in patients with facial flat warts.Methods:A total of 109 patients with facial flat warts who visited our hospital from May 2020 to March 2023 were randomly divided into a control group(55 cases,2 cases were excluded,and 53 cases were finally completed)and an observation group(54 cases,1 case was excluded,and 53 cases were finally completed)using a random number table method.The control group was treated with photodynamic therapy alone,and the observation group was treated with photodynamic therapy after CO_(2) fractional laser pretreatment.The total effective rate and recurrence rate at 6 months follow-up were compared between the two groups.The changes in inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and interferon-γ(INF-γ)]and lesion symptom scores before and after treatment were observed in the two groups.Results:The overall efficacy of the observation group was higher than that of the control group(P<0.05).There was no difference in inflammatory factors between the two groups before treatment(P>0.05).The inflammatory factors decreased after treatment in both groups,and the difference in inflammatory factors before and after treatment in the observation group was greater than that in the control group(P<0.05).There was no difference in lesion symptom scores between the two groups before treatment.The number,size,color,thickness,itching degree,and isomorphic reaction scores of lesions decreased after treatment in both groups,and the difference in lesion symptom scores before and after treatment in the observation group was greater than that in the control group(P<0.05).After 6 months of follow-up,the recurrence rate in the observation group was 3.701%(1/27 cases)compared with 25.00%(4/16 cases)in the control group,which was not statistically significant(P>0.05).Conclusion:CO_(2) fractional laser pretreatment combined with photodynamic therapy can reduce inflammatory response,alleviate symptoms,and improve the efficacy in patients with facial flat warts.