血清S100β联合IL-6在急诊脓毒症患者脑损伤中的预测价值分析

Predictive value of serum S100βcombined with IL-6 in brain injury in patients with emergency sepsis

目的分析血清中枢神经特异蛋白(S100β)联合白细胞介素6(interleukin 6,IL-6)在急诊脓毒症患者脑损伤中的预测价值。方法以2021年3月至2022年9月周口市中心医院收治的107例急诊脓毒症患者为研究对象,检测患者血清S100β及IL-6水平。根据患者脑损伤发生情况将107例患者分为脑损伤组(n=42)及未损伤组(n=65)。采用Cox回归分析探讨急诊脓毒症患者脑损伤的独立危险因素,采用受试者工作特征(receiver operating characteristic,ROC)曲线分析血清S100β及IL-6水平在急诊脓毒症患者脑损伤中的预测价值。结果脑损伤组患者血清S100β(0.89±0.17)及IL-6(31.14±4.53)水平与未损伤组(S100β:0.68±0.12;IL-6:20.67±3.18)相比显著升高(P<0.001)。年龄≥55岁、APACHEⅡ评分高、SOFA评分高、血糖高水平、BUN高水平、S100β高水平及IL-6高水平是急诊脓毒症患者发生脑损伤的独立危险因素(P<0.05)。血清S100β联合IL-6预测急诊脓毒症患者脑损伤的AUC为0.977(P<0.05),高于任一指标的单独预测效能。当血清S100β水平高于0.798 ng/mL及IL-6水平高于25.58 ng/L时,急诊脓毒症患者发生脑损伤的风险增加。结论急诊脓毒症脑损伤患者血清S100β及IL-6水平显著升高,且血清S100β联合IL-6对急诊脓毒症患者脑损伤具有较高的预测价值。

Objective To analyze the predictive value of serum central nerve specific protein(S100β)combined with interleukin-6(IL-6)in brain injury in patients with emergency sepsis.Methods The serum S100β and IL-6 levels of 107 patients with emergency sepsis admitted to Zhoukou Central Hospital from March 2021 to September 2022 were detected.According to the occurrence of brain injury,107 patients were divided into brain injury group(n=42)and uninjured group(n=65).Cox regression analysis was used to investigate the independent risk factors of brain injury in patients with emergency sepsis,and receiver operating characteristic(ROC)curve was used to analyze the predictive values of serum S100β and IL-6 levels in brain injury in patients with emergency sepsis.Results The levels of serum S100β(0.89±0.17)and IL-6(31.14±4.53)in brain injury group were significantly higher than those in uninjured group(S100β:0.68±0.12;IL-6:20.67±3.18)(P<0.001).Age≥55 years old,high APACHEⅡ score,high SOFA score,high blood glucose level,high BUN level,high S100β level,and high IL-6 level were independent risk factors for brain injury in emergency sepsis patients(P<0.05).The AUC of serum S100β combined with IL-6 in predicting brain injury in patients with emergency sepsis was 0.977(P<0.05),which was higher than that of any index alone.When serum S100β level was higher than 0.798 ng/mL and IL-6 level was higher than 25.58 ng/L,there was an increased risk of brain injury in patients with emergency sepsis.Conclusion Serum S100β and IL-6 levels were significantly increased in patients with emergency sepsis brain injury,and serum S100β combined with IL-6 had high predictive value for brain injury in emergency sepsis patients.