《第28届急性疾病质量倡议工作组共识报告:脓毒症相关急性肾损伤》解读

Interpretation for"sepsis associated acute kidney injury:consensus report of the 28th Acute Disease Quality Initiative Workgroup"

脓毒症相关急性肾损伤(sepsis associated acute kidney injury,SA-AKI)被定义为脓毒症背景下急性肾损伤(acute kidney injury,AKI)的存在。在遗传易感性的背景下,脓毒症可通过多种机制导致SA-AKI的发生,基于病理生理机制的差异,SA-AKI归属于不同的“内型”,且表现为不同的“亚表型”。生物标志物和预测模型的结合具备早期识别AKI高风险患者和明确SA-AKI“内型”的潜力。容量复苏及血液净化是SA-AKI治疗的优化策略。此外,基于儿童的SA-AKI临床研究值得期待。

Sepsis-associated acute kidney injury(SA-AKI)is defined as the presence of acute kidney injury(AKI)in the context of sepsis.In the setting of genetic susceptibility,sepsis can lead to SA-AKI through various mechanisms.Based on differences in pathophysiological mechanisms,SA-AKI is categorized into different"endotypes"and manifests as distinct"subtypes".The combination of biomarkers and predictive models has the potential to early identify high-risk AKI patients and elucidate SA-AKI"endotypes".Volume resuscitation and blood purification are optimized strategies for SA-AKI treatment.Furthermore,clinical research on SA-AKI in children is promising.