右佐匹克隆联合谷维素片治疗围绝经期女性焦虑性失眠的疗效及对相关神经递质的影响

Curative efficacy of dexzopiclone plus oryzanol tablet on anxiety insomnia and its influences on related neurotransmitters in perimenopausal women

目的:分析右佐匹克隆辅助谷维素片治疗围绝经期女性焦虑性失眠的疗效及对神经递质的影响。方法:选择2020年1月至2023年1月期间衡水市人民医院就诊的202例围绝经妇女,分为对照组(右佐匹克隆片)和观察组(右佐匹克隆片联合谷维素片)。治疗前后,采用PSQI和HAMA评估患者睡眠质量和焦虑状况;检测患者血清5-羟色胺(5-HT)、γ-氨基丁酸(GABA)、去甲肾上腺素(NE)、多巴胺(DA)、脑源性神经营养因子(BDNF)、神经营养因子3(NT-3)、神经生长因子(NGF)、促卵泡生成素(FSH)、促黄体生成素(LH)和雌二醇(E2)水平;统计患者不良反应情况。结果:治疗后,观察组失眠患者PSQI和HAMA评分明显低于对照组(P<0.05)。观察组睡眠质量明显更好,焦虑程度明显更轻(P<0.05)。观察组失眠患者5-HT、GABA、BDNF、NT-3、NGF、E2水平明显高于对照组,NE、DA、FSH和LH水平明显低于对照组(P<0.05)。2组不良反应发生率间差异无统计学意义(P>0.05)。结论:右佐匹克隆联合谷维素片可改善围绝经期女性焦虑性失眠症状。

OBJECTIVE To explore the curative efficacy of dexzopiclone assisted oryzanol tablets on anxiety insomnia and its influences on neurotransmitters in perimenopausal women.METHODS Between January 2020 and January 2023,202 perimenopausal women hospitalized at Hengshui People's Hospital were recruited.They were assigned into two groups of control(dexzopiclone tablets)and observation(dexzopiclone tablets plus oryzanol tablets).Before and after treatment,sleep quality and anxiety status of subjects were evaluated by Pittsburgh sleep quality index(PSQI)and Hamilton anxiety scale(HAMA).The serum levels of 5-hydroxytryptamine(5-HT),γ-aminobutyric acid(GABA),noadrenaline(NE),dopamine(DA),brain-derived neurotrophic factor(BDNF),neurotrophic factor 3(NT-3),nerve growth factor(NGF),follicle-stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)were detected.Adverse reactions were statistically compared.RESULTS After treatment,points of PSQI/HAMA were significantly lower in observation group than those in control group(P<0.05).As compared with control group,sleep quality was significantly better and anxiety degree significantly milder in observation group(P<0.05).The levels of 5-HT,GABA,BDNF,NT-3,NGF and E2 were significantly higher in observation group than those in control group while the levels of NE,DA,FSH and LH significantly lower than those in control group(P<0.05).No significant inter-group difference existed in the incidence of adverse reactions(P>0.05).CONCLUSION Dexzopiclone plus oryzanol tablets may improve anxiety insomnia in perimenopausal women.