摘要
越来越多的实验和人群研究发现,环境内分泌干扰物(endocrine disrupting chemicals,EDCs)除了干扰免疫、神经和生殖等系统的正常功能,还能够影响机体正常脂质代谢。EDCs依赖过氧化物酶体增殖物激活受体γ(peroxisome proliferator activated receptorγ,PPARγ)介导脂肪分化是当前研究的热点。本文围绕PPARγ结构特征、生理功能,以及EDCs对PPARγ的表达调控进行综述,旨在为全面评估EDCs的健康风险提供参考。
Mounting evidence from experiment and population studies has shown that environmental endocrine chemicals(EDCs)can also affect the normal lipid metabolism of the body,in addition to interfere with the normal function of immune,nervous,reproductive and other systems.The peroxisome proliferator-activated receptorγ(PPARγ)mediated adipose differentiation is a hot topic in EDCs studies.ln this review,the structural characteristics,physiological functions of PPARγ,and the regulation of PPARγexpression by EDCs were systemically introduced,intending to provide reference for a comprehensive assessment of the health risks of EDCs.
作者
曹亚强
苗轲
高旭
俞建霞
许滋宁
陈圆圆
CAO Yaqiang;MIAO Ke;GAO Xu;YU Jianxia;XU Zining;CHEN Yuanyuan(Department of Environment and Radiology,Nantong Center for Disease Control and Prevention,Nantong Jiangsu,226007,China;Key Laboratory of Environment and Population Health,National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing,100021,China;The Fifth People's Hospital of Haimen District,Nantong Jiangsu,226100,China)
出处
《职业与健康》
CAS
2024年第5期711-715,共5页
Occupation and Health
基金
国家自然科学基金青年基金项目(22206178)。
关键词
内分泌干扰物
核受体
脂质代谢
肥胖
Endocrine disruptors chemicals
Nuclear receptor
Lipid metabolism
Obesity
