线粒体定位的Sirtuin蛋白参与阿尔茨海默症的研究进展

Research progress of mitochondrial Sirtuins involved in Alzheimer's disease

阿尔茨海默症(AD)是一种慢性进行性中枢神经系统退行性病变,是老年人群中最常见的痴呆症形式。AD是一种复杂的异质性疾病,其发病涉及多种因素,包括遗传因素、神经递质因素、免疫因素和环境因素。Sirtuin家族蛋白在AD中发挥的作用日益受到广泛关注,Sirtuin家族调节AD疾病进程中的许多重要环节。尽管大量研究聚焦于Sirtuin1和2在AD及其他神经退行性疾病中的重要作用,但定位于线粒体的Sirtuin3、4、5的研究相对较少。本文将回顾定位于线粒体的Sirtuin家族蛋白参与AD发病机理的研究进展,这对于阐明AD的发生发展机制与AD的防治具有重要意义。

Alzheimer's disease(AD)is a chronic progressive degenerative disease of the central nervous system,and is the most common form of dementia in the elderly.AD is a complex heterogeneous disease,and its pathogenesis involves multiple factors,including genetic factors,neurotransmitter factors,immune factors and environmental factors.The role of Sirtuin family proteins in AD has attracted increasing attention.The Sirtuin family regulates many important links in the progression of AD.Although a large number of studies have focused on the important role of Sirtuinl and 2 in AD and other neurodegenerative diseases,there are relatively few studies on mitochondrial Sirtuin3,4,5.This article will review the research progress of mitochondrial Sirtuin family proteins in the pathogenesis of AD,which is of great significance for elucidating the occurrence and development mechanism of AD and the prevention and treatment of AD.