APOA1和Genisini评分与冠状动脉粥样硬化快速进展密切相关

APOA1 and Genisini score are closely associated with rapid progression of coronary atherosclerosis

目的:探讨冠状动脉(冠脉)粥样硬化快速进展患者的血脂动态演变过程及影响因素。方法:收集2018年6月—2022年2月在安徽医科大学第一附属医院心内科住院,且在10(5~12)个月内进行过两次冠脉造影的患者201例,根据冠脉病变的进展,分为缓慢进展组(100例)和快速进展组(101例)。比较两组病史、用药、血管造影特征和血脂演变,采用logistic回归分析影响因素。结果:与缓慢进展组比较,快速进展组患者第1次造影时的Gensini评分更高,病变血管数更多,APOA1的差值存在统计学差异。多因素logistic回归分析结果显示,冠脉粥样硬化快速进展的独立影响因子有冠脉Gensini评分(OR=1.020,P=0.000)和APOA1的差值(OR=6.097,P=0.029)。结论:Genisini评分及APOA1降低幅度是冠脉粥样斑块病变快速进展的独立影响因素。

Objective To investigate the dynamic evolution of blood lipids and its influencing factors in patients with rapid progression of coronary artery atherosclerosis.Methods A total of 201 patients admitted to the Department of Cardiology,the First Affiliated Hospital of Anhui Medical University from June 2018 to February 2022 who underwent coronary angiography twice within 10(5-12)months were collected.According to the progression of coronary lesions,they were divided into slow progression group(100 cases)and fast progression group(101 cases).The medical history,medication,angiographic features and lipid evolution of the two groups were compared,and the influencing factors were analyzed by regression.Results Compared with the slow progression group,Gensini score increased and stenosis vessels were more as well as the difference of APOA1 decreased in the fast progression group.Multivariate logistic regression analysis showed that the Gensini score(OR=1.020,P=0.000)and APOA1(OR=6.097,P=0.029)were the independent factors in the rapid progression of coronary atherosclerosis.Conclusion Genisini score and APOA1 reduction are independent factors in the rapid progression of coronary atherosclerotic plaque.