放疗联合免疫治疗所致肺毒性的影响因素研究进展

Factors Influencing Pulmonary Toxicity Induced by Combination Radiotherapy with Immunotherapy

放射治疗和免疫治疗协同调节免疫反应的机制可能影响治疗相关的毒性和严重程度,尤其是联合治疗所导致的肺毒性。无论是放射性肺损伤,还是免疫相关性肺炎,都会严重影响患者的治疗疗效和生存质量。全文就放疗联合免疫治疗的疗效及进展、所致肺毒性的机制以及所致肺毒性的影响因素作一综述。

The combination of radiotherapy and immunotherapy synergistically modulates the immune response,which may affect the treatment-related toxicity and its severity,particularly the pulmonary toxicity.Both radiation-induced lung injury and immue-related pneumonitis can seriously impact the treatment efficacy and the quality of survival for patients.This paper reviews the current research progress on the pulmonary toxicity induced by radiotherapy combined with immunotherapy and its influencing factors.