D-二聚体和血小板计数预测过敏性紫癜性肾炎的价值

Value of D-dimer and platelet count in predicting Henoch-Schonlein purpura nephritis

目的探讨D-二聚体和血小板计数预测过敏性紫癜性肾炎(HSPN)的价值。方法按照有无肾损害将68例过敏性紫癜(HSP)患儿分为HSP无肾炎组(A组,38例)和HSPN组(B组,30例)。分析D-二聚体和血小板计数预测HSPN的价值。结果与A组比较,B组D-二聚体和血小板计数升高(P<0.05)。单因素logistic回归分析显示,D-二聚体和血小板计数升高是影响HSPN的危险因素(P<0.05);ROC曲线分析显示,D-二聚体和血小板计数预测HSPN的曲线下面积分别为0.903和0.846(P<0.05),其预测HSPN的灵敏度与特异度均高于80%。结论HSPN患儿具有更高的D-二聚体和血小板计数,两者升高是影响HSPN的危险因素,提示临床上对D-二聚体或血小板计数明显升高的HSP患儿应及时治疗,密切观察,以尽量减少HSPN的发生。

Objective To explore the value of D-dimer and platelet count in predicting Henoch-Schönlein purpura nephritis(HSPN).Methods A total of 68children diagnosed with Henoch-Schönlein purpura(HSP)were divided into two groups of A(without nephritis,38cases)and B(with HSPN,30cases).The value of D-dimer and platelet count in predicting HSPN was analyzed.Results The levels of D-dimer and platelet count in group B were significantly higher than those in group A(P<0.05).Univariate logistic regression analysis showed that higher D-dimer and platelet count were the risk factors for HSPN(P<0.05).The AUC values for D-dimer and platelet count were 0.903and 0.846,respectively and the sensitivity and specificity in predicting HSPN were over 80%.Conclusion The children with HSPN have higher D-dimer and platelet count.The increase of both D-dimer and platelet count are the risk factors for HSPN,suggesting that HSP children with increased D-dimer and platelet count should be treated promptly and observed closely to minimize the occurrence of HSPN.