氯雷他定联合匹多莫德辅助利巴韦林治疗反复呼吸道感染的效果

Effect of Loratadine Combined with Pidotimod Assisted with Ribavirin in the Treatment of Recurrent Respiratory Tract Infection

目的:探讨氯雷他定联合匹多莫德辅助利巴韦林治疗反复呼吸道感染(Recurrent respiratory infections,RRI)的效果。方法:选定本院2021年7月—2023年9月收治的120例RRI患者,简单随机法分为试验组(60例,利巴韦林、氯雷他定联合匹多莫德)与对照组(60例,利巴韦林)。观察两组咽部正常时间、肺啰音消失时间、咳嗽缓解时间、炎症因子[C反应蛋白(C-reactive protein,CRP)、粒细胞-巨噬细胞集落刺激因子(Granulocyte macrophage colony factor,GM-CSF)]、免疫功能[免疫球蛋白A(Immunoglobulin A,IgA)、免疫球蛋白G(Immunoglobulin G,IgG)、免疫球蛋白M(Immunoglobulin M,IgM)及自然杀伤细胞(natural killer cell,NK细胞)]。结果:试验组咽部正常时间、肺啰音消失时间、咳嗽缓解时间短于对照组(P<0.05);试验组治疗后CRP、GM-CSF水平低于对照组,IgA、IgG、IgM及NK细胞水平高于对照组(P<0.05)。结论:利巴韦林、氯雷他定联合匹多莫德有助于减轻RRI患者的炎症反应,改善其免疫功能,并促使其快速恢复。

Objective:To investigate the efcacy of loratadine combined with pidotimod and ribavirin in the treatment of recurrent respiratory infections(RRI).Methods:A total of 120 patients with RRI admitted to our hospital from July 2021 to September 2023 were selected and randomly divided into experimental group(60 patients,ribavirin,loratadine combined with pidotimod)and control group(60 patients,ribavirin).The pharyngeal normal time,lung rale disappearance time,cough relief time,infammatory factors[C-reactive protein(CRP),granulocyte macrophage colony stimulating factor(GM-CSF)],immune function[Immunoglobulin A(IgA),Immunoglobulin G(IgG),Immunoglobulin M(IgM)and natural killer cell(NK cell)]were observed in the two groups.Results:The pharyngeal normal time,lung rale disappearance time and cough relief time in the experimental group were shorter than those in the control group(P<0.05).After treatment,the levels of CRP and GM-CSF in the experimental group were lower than those in the control group,and the levels of IgA,IgG,IgM and NK cells were higher than those in the control group(P<0.05).Conclusion:Ribavirin,loratadine combined with pidotimod can help reduce the inflammatory response in patients with RRI,improve their immune function,and promote their rapid recovery.