七味白术散加减治疗小儿厌食症临床观察

Therapeutic effect of modified Qiwei Baizhu Powder on anorexia in children

目的观察七味白术散加减治疗小儿厌食症的治疗效果。方法将54例小儿厌食症患者按照随机数字表法分为2组,对照组27例予常规西医治疗,治疗组27例在对照组基础上联合七味白术散加减治疗。2组均治疗1个月。比较2组治疗前后中医症状评分、主食食量、体质量、血清锌浓度,并统计2组的临床疗效、不良反应情况、治疗后6个月的复发情况。结果2组治疗后主症、次症评分及总分均较本组治疗前降低(P<0.05),且治疗组治疗后均低于对照组(P<0.05)。2组治疗后主食食量、体质量均较本组治疗前升高(P<0.05),且治疗组治疗后均高于对照组(P<0.05)。2组治疗后血清锌浓度均较本组治疗前升高(P<0.05),且治疗组治疗后高于对照组(P<0.05)。治疗组临床疗效优于对照组(P<0.05)。2组治疗期间均未出现严重不良反应。治疗组复发率低于对照组(P<0.05)。结论针对厌食症患儿,采用七味白术散加减联合西药治疗,可有效改善患儿症状,提升主食食量及体质量,改善血清锌浓度,降低复发率,具有良好的安全性。

Objective To analyze the therapeutic effect of modified Qiwei Baizhu Powder on anorexia in children.Methods A total of 54 children with anorexia were randomlyassigned to control group(n=27)or treatment group(n=27).All patients were treated with routine Western medicine(RWM),and those in the treatment group were treated with modified QiweiBaizhu Powder plus RWM.A 1-month treatment was performed in both groups.The aim was to compare traditional Chinese medicine(TCM)symptom score,staple food intake,body mass index(BMI),and serum zinc concentration before and after treatment.The therapeutic effect,adverse reactions and 6-month recurrence were assessed between groups.Results After treatment,the scoresof main symptoms and secondary symptomswere significantly lower than those before treatment(P<0.05),and which in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,staple food intake,BMI and serum zinc concentration in the both groups were significantly increased than those before treatment(P<0.05),andthe increases were more pronounced in treatment group(P<0.05).After treatment,the therapeutic effectin the treatment group was better than that of the control group(P<0.05).No serious adverse reactions occurred in the two groups.The recurrence rate in the treatment group was significantly lower than that of the control group(P<0.05).Conclusion For the children with anorexia,the combination of modifiedQiwei Baizhu Powder and RWM can effectively improve their symptoms,increase staple food intake and BMI,improve serum zinc concentration level,and reduce recurrence rate.It has a good safety.