代谢相关脂肪性肝病无创血清学诊断的研究进展

Advances in serological non-invasive diagnosis for metabolic dysfunction-associated fatty liver disease

代谢相关脂肪性肝病是以代谢异常相关的肝脂肪变性为特征的慢性肝病,可进展至代谢相关脂肪性肝炎、肝纤维化和肝硬化,甚至肝细胞癌。目前,肝活组织检查仍是诊断的金标准,但由于肝活组织检查的有创性和并发症风险,开发血清学诊断指标以实现无创性诊断是近年来研究的热点。现对目前研究较充分的脂肪肝无创性血清学诊断指标进行综述。

Metabolic dysfunction-associated fatty liver disease is a chronic liver condition associated with metabolic abnormalities characterized by hepatic steatosis that can progress to metabolic-related steatohepatitis,liver fibrosis,cirrhosis,and even hepatocellular carcinoma.Currently,a liver biopsy is still the gold standard for diagnosis but due to its invasiveness and risk of complications,the development of serological diagnostic indicators to achieve non-invasive diagnosis has been a hot research topic in recent years.Herein,well-researched serological non-invasive diagnostic indicators present now for fatty livers are reviewed.