三七治疗动脉粥样硬化药理机制研究进展

Research Progress on Pharmacological Mechanism of Sanqi(Notoginseng Radix Et Rhizoma)on Treating Atherosclerosis

动脉粥样硬化(atherosclerosis,AS)是引发心脑血管系统疾病的主要原因之一,是动脉内膜异常沉积日久所致的慢性炎症性疾病,病机复杂、治疗周期长久,是临床需要重点解决的重点疾病之一。其病理机制涉及血管平滑肌细胞增殖、内皮损伤、血管内血栓形成、炎症反应、脂质代谢异常、氧化应激加剧、自噬稳态失衡等,而当前对中药三七有效成分是近年来研究的热点和重点,其富含多种皂苷类和非皂苷类有效化学成分,能够综合调理多方面的通路、分子机制,达到减轻炎症反应和内皮损伤,恢复正常脂质代谢、重新调整自噬稳态等的平衡,抑制血管内血栓形成、血管平滑肌细胞增殖,并最终达到预防和治疗AS的目的。鉴于三七在抗AS中的重要作用,该文就三七及其有效成分对AS保护作用的体内外等研究进行综述,为中医药新产品研究开发及临床应用辨证治疗用药提供参考和依据。

Atherosclerosis(AS)is one of the main causes of cardiovascular and cerebrovascular diseases.It is a chronic inflammatory disease caused by abnormal deposition of arterial intima for a long time.With complex pathogenesis and long treatment cycle,it is one of the key diseases that need to be addressed in clinical practice.Its pathological mechanisms involve vascular smooth muscle cell proliferation,endothelial damage,intravascular thrombosis,inflammatory response,abnormal lipid metabolism,increased oxidative stress,and imbalance of autophagy homeostasis.Currently,the active ingredients of traditional Chinese medicine Sanqi(Notoginseng Radix Et Rhizoma)have been a hot topic and focus of research in recent years.They are rich in various saponin and non saponin effective chemical components,which can comprehensively regulate various pathways and molecular mechanisms,achieving the reduction of inflammatory response and endothelial damage,Restore normal lipid metabolism,readjust the balance of autophagy homeostasis,inhibit intravascular thrombosis,proliferation of vascular smooth muscle cells,and ultimately achieve the goal of preventing and treating AS.Given the important role of Sanqi(Notoginseng Radix Et Rhizoma)in anti AS,this article reviews the in vivo and in vitro studies on the protective effects of Sanqi(Notoginseng Radix Et Rhizoma)and its active ingredients on AS,providing reference and basis for the research and development of new traditional Chinese medicine products and clinical application of dialectical treatment drugs.