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硝苯地平联合利托君治疗先兆早产对足月分娩率的影响研究

Study on the Effect of Nifedipine Combined with Ritodrine on the Full-Term Delivery Rate in the Treatment of Threatened Preterm Labor
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摘要 目的研究硝苯地平联合利托君治疗先兆早产对足月分娩率的影响。方法按照随机数字表法将平顶山市妇幼保健院2022年2月至2023年10月期间收治的72例先兆早产患者分为观察1组(单一应用硝苯地平治疗),观察2组(单一应用利托君治疗)及联合组(联合硝苯地平与利托君治疗),每组各24人。观察三组患者治疗效果、生化指标、妊娠情况、用药不良反应及新生儿结局情况。结果联合组治疗有效率(91.67%)高于观察1组(66.67%)、观察2组(62.50%),三组相比较,差异有统计学意义(P<0.05)。治疗后,联合组患者白细胞介素-17、子宫内膜抗体水平下降,转化生长因子-β、可溶性人类白细胞抗原-G指标增加,三组生化指标比较,差异有统计学意义(P<0.05)。联合组患者宫缩消失时间比观察1组、观察2组短,孕期延长时间比观察1组、观察2组长,分娩孕周比观察1组、观察2组晚,且联合组保胎成功率高于观察1组、观察2组,差异有统计学意义(P<0.05)。联合组患者用药不良反应发生率与观察1组、观察2组对比,差异无统计学意义(P>0.05)。联合组新生儿死亡率(8.33%)低于观察1组(33.33%)、观察2组(37.50%),且新生儿窒息率(8.33%)低于观察1组(41.67%)、观察2组(37.50%),新生儿Apgar评分高于观察1组、观察2组,联合组新生儿情况较好,差异有统计学意义(P<0.05)。结论应用硝苯地平联合利托君治疗能有效抑制患者宫缩作用,改善临床症状以及生化指标,延长孕期,提高足月分娩率,且安全性较高,避免不良反应,新生儿情况良好,临床有一定的应用价值。 Objective To study the effect of nifedipine combined with ritodrine in the treatment of threatened preterm labor on the full-term delivery rate.Methods According to the random number table method,72 patients with threatened preterm labor admitted to Pingdingshan Maternal and Child Health Hospital from February 2022 to October 2023 were divided into observation group 1(treated with nifedipine alone),observation group 2(treated with ritodrine alone)and combined group(treated with nifedipine and ritodrine),with 24 people in each group.The treatment effects,biochemical indicators,pregnancy conditions,adverse drug reactions and neonatal outcomes of the three groups of patients were observed.Results The effective rate of treatment in the combined group(91.67%)was higher than that in observation group 1(66.67%)and observation group 2(62.50%),and the difference was statistically significant(P<0.05).After treatment,the levels of interleukin-17 and endometrial antibodies in the combined group decreased,and the indicators of transforming growth factor-βand soluble human leukocyte antigen-G increased.The difference in biochemical indicators among the three groups was statistically significant(P<0.05).The time for uterine contractions to disappear in the combined group was shorter than that in observation group 1 and observation group 2,the pregnancy extension time was longer than that in observation group 1 and observation group 2,the delivery gestational week was later than that in observation group 1 and observation group 2,and the success rate of tocolysis in the combined group was higher than that in observation group 1 and observation group 2,the difference was statistically significant(P<0.05).The incidence of adverse drug reactions in the combined group was compared with that in observation group 1 and observation group 2, and the difference was not statistically significant (P > 0.05). The neonatal mortality rate (8.33%) in the combined group was lower than that in observation group 1 (33.33%) and observation group 2 (37.50%), and the neonatal asphyxia rate (8.33%) was lower than that in observation group 1 (41.67%) and observation group 2 (37.50%). The neonatal Apgar score was higher than that in observation group 1 and observation group 2. The neonatal condition in the combined group was better, and the difference was statistically significant (P < 0.05). Conclusion The application of nifedipine combined with ritodrine can effectively inhibit the contraction of the patient’s uterus, improve clinical symptoms and biochemical indicators, prolong pregnancy, increase the full-term delivery rate, and has high safety, avoids adverse reactions, and the neonatal condition is good, which has certain clinical application value.
作者 王亚丹 杜幸琴 杨亚楠 秦灿峰 杨子 关慧慧 WANG Yadan;DU Xingqin;YANG Yanan;QIN Canfeng;YANG Zi;GUAN Huihui(Department of Obstetrics and Gynecology,Pingdingshan Maternal and Child Health Hospital,Pingdingshan Henan 467000,China)
出处 《临床研究》 2024年第6期61-64,共4页 Clinical Research
关键词 硝苯地平 利托君 先兆早产 足月分娩 妊娠 宫缩 nifedipine ritodrine threatened preterm labor full-term delivery pregnancy uterine contraction
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