血清IL-6和胃蛋白酶原Ⅰ/Ⅱ比值对老年胃癌患者预后评估的价值分析

Value Analysis of Serum IL-6 and Pepsinogen I/II Ratio on the Prognosis Assessment for Elderly Gastric Cancer Patients

目的分析与讨论血清白细胞介素-6(IL-6)与胃蛋白酶原(PG)Ⅰ/Ⅱ比值对老年胃癌患者预后评估价值。方法筛选2020年5月至2021年5月经手术治疗的75例老年胃癌患者进行回归性分析,分别使用胶乳免疫比浊法、磁微粒化学发光对患者PGⅠ/Ⅱ与IL-6水平进行检测,并且以logistic回归分析老年胃癌患者预后不良危险因素,评估血清IL-6与PGⅠ/Ⅱ比值对患者预后预测价值。结果截止2023年5月,75例患者经随访,无失访人员,随访时间为20~30个月,平均(25.63±3.25)个月。经随访,预后不良患者共29例,发生率38.67%,设定为预后不良组;预后良好患者共46例,设定为预后良好组;单因素分析结果显示,组织学分化、TNM分期、IL-6水平和PGⅠ/Ⅱ比值是老年胃癌患者预后的影响因素,差异有统计学意义(P<0.05),而年龄、肿瘤大小、合并疾病、受教育程度与老年胃癌患者预后无关,差异无统计学意义(P>0.05);经多因素logistic回归分析,结果显示,组织学分化、TNM分期、IL-6、PGⅠ/Ⅱ比值均为老年胃癌预后不良危险因素,差异有统计学意义(P<0.05)。结论血清IL-6与PGⅠ/Ⅱ比值能预测老年胃癌患者预后情况,具有重要价值。

Objective To discuss the clinical value of serum interleukin-6(IL-6)and pepsinogenⅠ/Ⅱ(PGⅠ/Ⅱ)on the prognosis assessment for elderly gastric cancer patients.Methods A total of 75 elderly gastric cancer patients treated from May 2020 to May 2021 in Yongmei Group General Hospital were reviewed.PGⅠ/Ⅱand IL-6 values were measured through the latex-enhanced immunoturbidimetry and magnetic particle chemiluminescence method.Logistic regression equation was used to analyze the risk factors of the elderly gastric cancer patient’s clinical prognosis.The clinical value of serum IL-6 and PGⅠ/Ⅱon the assessment of surgical prognosis was studied.Results Till May 2023,75 patients have been followed up with no missing individuals.Patients were followed for 20~30 months,with an average value of(25.63±3.25)months.After follow-up,there were a total of 29 patients with poor prognosis,with an incidence rate of 38.67%,and they were designated as the poor prognosis group;A total of 46 patients with good prognosis were designated as the group with good prognosis;The results of univariate analysis showed that histological differentiation,TNM stages,IL-6 levels and PGⅠ/Ⅱvalues were statistically significant factors affecting the prognosis of elderly gastric cancer patients(P<0.05);there were no correlations with the patient’s age,tumor size,complicated disease and education background,and the differences were not statistically significant(P>0.05);the multivariate Logistic regression equation showed that histological differentiation,TNM staging,IL-6,and PGⅠ/Ⅱratio were all statistically significant risk factors for poor prognosis of elderly gastric cancer(P<0.05).Conclusion The ratio of serum IL-6 to PGⅠ/Ⅱcan predict the prognosis of elderly gastric cancer patients and has important value.