去氢骆驼蓬碱改善阿尔茨海默病作用及其机制研究进展

Research Progress on the Therapeutic Effect and Mechanism of Harmine in Alzheimer's Disease

去氢骆驼蓬碱(HM)是一种在自然界中丰富存在的β-咔啉类生物碱,具有多种生物学作用。近年体内外研究发现,HM对阿尔茨海默病(AD)具有明显改善作用。其机制可能与HM降低β-淀粉样蛋白(Aβ)异常沉积和Tau蛋白过度磷酸化、调节胆碱能系统、抗氧化应激和神经炎症等作用有关。该文综述HM改善AD的作用及其机制研究进展,以期为HM的临床应用和AD防治药物的开发提供参考。

Harmine(HM)is a type ofβ-Carboline alkaloid abundant in nature and has many biological effects.In recent years.Studies have found that HM had a significant positive effect on Alzheimer's disease(AD)both in vivo and in vitro.Its mechanism may be related to the reduction of abnormal deposition ofβ-amyloid protein(Aβ),excessive phosphorylation of Tau protein,regulation of the cholinergic system,antioxidant stress,and antineuritis.This article reviews the research progress on the improvement effect and mechanism of HM in AD in order to provide an experimental basis for the clinical application of HM and the development of drugs in the area of AD the prevention and treatment.