低分子肝素皮下注射辅助治疗慢性阻塞性肺疾病急性加重的效果分析

Effect Analysis of Low Molecular Weight Heparin Subcutaneous Injection in Adjuvant Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的:分析低分子肝素皮下注射辅助治疗慢性阻塞性肺疾病急性加重(AECOPD)的效果。方法:选取2022年1月-2023年8月金昌市永昌县第二人民医院收治的AECOPD患者320例作为研究对象,根据随机数字表法分为观察组和对照组,各160例。对照组给予常规治疗,观察组在对照组基础上给予依诺肝素钠注射液皮下注射。比较两组治疗效果、肺功能指标、炎性因子水平、不良反应发生情况。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.001)。治疗前,两组用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、呼气峰值流速(PEF)比较,差异无统计学意义(P>0.05);治疗后,两组FVC、FEV_(1)、PEF高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组C反应蛋白、白细胞介素-6、白细胞介素-8水平比较,差异无统计学意义(P>0.05);治疗后,两组C反应蛋白、白细胞介素-7、白细胞介素-8水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.001)。结论:低分子肝素皮下注射辅助治疗慢性阻塞性肺疾病急性加重的效果较好,可改善患者肺功能,减轻炎性反应,降低并发症发生率。

Objective:To analyze the effect of low molecular weight heparin subcutaneous injection in adjuvant treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:A total of 320 AECOPD patients admitted to Jinchang City Yongchang County Second People's Hospital from January 2022 to August 2023 were selected as the study subjects.They were divided into observation group and control group according to random number table method,with 160 cases in each group.The control group was given conventional treatment,and the observation group was given subcutaneous injection of enoxaparin sodium injection on the basis of the control group.The treatment effect,pulmonary function indexes,levels of inflammatory factors and adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.001).Before treatment,there was no significant difference in forced vital capacity(FVC),forced expiratory volume in 1 second(FEV_(1))and peak expiratory flow rate(PEF)between the two groups(P>0.05).After treatment,the FVC,FEV_(1) and PEF in the two groups were higher than those before treatment,these indexes in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of C-reactive protein,interleukin-6 and interleukin-8 between the two groups(P>0.05).After treatment,the levels of C-reactive protein,interleukin-7 and interleukin-8 in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,with a statistically significant difference(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.001).Conclusion:Subcutaneous injection of low molecular weight heparin in adjuvant treatment of acute exacerbation of chronic obstructive pulmonary disease has a good effect,and can improve pulmonary function,relieve inflammatory reaction and reduce the incidence of complications.