阿卡波糖联合甘精胰岛素治疗老年2型糖尿病的效果分析

Effect of Acarbose Combined with Insulin Glargine on Elderly Patients with Type 2 Diabetes Mellitus

目的:分析阿卡波糖联合甘精胰岛素治疗老年2型糖尿病的效果。方法:选取2020年2月-2023年2月衡水市人民医院收治的老年2型糖尿病患者100例作为研究对象,随机分为观察组和对照组,各50例。对照组采用甘精胰岛素治疗,观察组在对照组基础上采用阿卡波糖治疗。比较两组治疗效果。结果:治疗后,两组糖化血红蛋白、空腹血糖、餐后2 h血糖水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组血糖标准差、24 h血糖平均绝对值差、24 h血糖波动次数、平均血糖波动幅度低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组空腹胰岛素、胰岛素抵抗指数低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组凝血酶调节蛋白、血管性血友病因子、丙二醛、超氧化物歧化酶水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P=0.022)。结论:阿卡波糖联合甘精胰岛素治疗老年2型糖尿病的效果显著,可降低血糖水平,保持血糖稳定,改善血管内皮功能,减轻氧化应激反应,降低不良反应发生率。

Objective:To analyze the effect of acarbose combined with insulin glargine in the treatment of senile type 2 diabetes mellitus.Methods:A total of one hundred elderly patients with type 2 diabetes treated in Hengshui People's Hospital from February 2020 to February 2023 were selected as the study objects and randomly divided into observation group and control group,with fifty cases in each group.The control group was treated with insulin glargine,and the observation group was treated with acarbose based on the control group.The therapeutic effect of the two groups was compared.Results:After treatment,the levels of glycosylated hemoglobin,fasting blood glucose and 2 h postprandial blood glucose in 2 groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);after treatment,the standard deviation of blood glucose,the difference of 24 h average absolute value of blood glucose,the number of 24 h blood glucose fluctuation and the average blood glucose fluctuation amplitude of the two groups were lower than before treatment,and the observation group was lower than the control group,with statistical significance(P<0.05);after treatment,fasting insulin and insulin resistance index in 2 groups were lower than before treatment,and observation group was lower than control group,the difference was statistically significant(P<0.05);after treatment,the levels of thrombin regulatory protein,Von Willebrand factor,malondialdehyde and superoxide dismutase in 2 groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);the incidence of adverse reactions in observation group was lower than that in control group,and the difference was statistically significant(P=0.022).Conclusion:Acarbose combined with insulin glargine has a significant effect on the treatment of elderly type 2 diabetes mellitus,which can reduce blood glucose level,maintain blood sugar stability,improve vascular endothelial function,reduce oxidative stress reaction,and reduce the incidence of adverse reactions.