乙型肝炎肝硬化患者血糖、血脂、炎性因子水平与肝功能的相关性分析

Analysis on Correlation Between Blood Glucose,Blood Lipid,Inflammatory Factors and Liver Function in Patients with Hepatitis B Cirrhosis

目的:分析乙型肝炎肝硬化患者血糖、血脂、炎性因子水平与肝功能的相关性。方法:选取2020年1月-2022年12月上海市嘉定区中心医院收治的141例乙型肝炎肝硬化患者作为观察组,根据Child-Pugh分级标准分为A级组(n=44)、B级组(n=61)、C级组(n=36);另选取同期健康体检者50例作为对照组。检测并比较四组炎性因子、血糖、血脂、肝功能指标水平,分析炎性因子、血糖、血脂与肝功能的相关性。结果:四组可溶性细胞间黏附分子(sICAM)-1、白细胞介素-6(IL-6)、白细胞介素-8(IL-18)水平比较,对照组<A级组<B级组<C级组,差异有统计学意义(P<0.05)。四组空腹血糖(FBG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、甘油三酯(TG)水平比较及任意两组比较,差异无统计学意义(P>0.05)。四组丙氨酸氨基转移酶(ALT)水平比较,对照组<A级组<B级组<C级组,四组白蛋白(ALB)水平比较,对照组>A级组>B级组>C级组,差异有统计学意义(P<0.05)。乙型肝炎硬化患者sICAM-1、IL-6、IL-18水平与ALT水平呈正相关,与血浆ALB水平呈负相关(P<0.05);FBG、LDL-C、HDL-C、TC、TG水平与ALT、ALB水平无相关性(P>0.05)。结论:乙型肝炎肝硬化患者炎性因子水平与ALT水平呈正相关,与血浆ALB水平呈负相关,可为乙型肝炎肝硬化患者的病情评估及后续诊治提供一定参考。

Objective:To analyze the correlation between blood sugar,blood lipid,inflammatory factors and liver function in patients with hepatitis B cirrhosis.Methods:A total of 141 patients with hepatitis B cirrhosis admitted to Shanghai Jiading District Central Hospital from January 2020 to December 2022 were selected as the observation group.They were divided into grade A group(n=44),grade B group(n=61)and grade C group(n=36)according to Child-Pugh classification standard.Another 50 healthy subjects for physical examination during the same period were selected as the control group.The levels of inflammatory factors,blood glucose,blood lipid and liver function index of the four groups were detected and compared.The correlation between inflammatory factors,blood glucose,blood lipid and liver function was analyzed.Results:The levels of soluble intercellular adhesion molecule(sICAM)-1,interleukin-6(IL-6)and interleukin-8(IL-18)were compared among four groups,and ranked as the control group<grade A group<grade B group<grade C group.The differences were statistically significant(P<0.05).There was no significant difference in the levels of fasting blood glucose(FBG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),total cholesterol(TC)and triglyceride(TG)among the four groups and between any two groups(P>0.05).Alanine aminotransferase(ALT)levels were compared among the four groups and ranked as the control group<grade A group<grade B group<grade C group,while albumin(ALB)levels were compared among the four groups and ranked as the control group>grade A group>grade B group>grade C group,and the differences were statistically significant(P<0.05).The levels of sICAM-1,IL-6 and IL-18 in patients with hepatitis B cirrhosis were positively correlated with ALT level,and negatively correlated with plasma ALB level(P<0.05).There was no correlation between FBG,LDL-C,HDL-C,TC,TG levels and ALT,ALB levels(P>0.05).Conclusion:The level of inflammatory factors in patients with hepatitis B cirrhosis is positively correlated with ALT level and negatively correlated with plasma ALB level,which can provide some reference for the evaluation and follow-up diagnosis and treatment of patients with hepatitis B cirrhosis.