氟化氨银预防及抑制龋齿的Meta分析

Meta-analysis of prevention and inhibition of dental caries by Silver diamine fluoride

目的全面系统评价氟化氨银(Silver diamine fluoride,SDF)的临床应用效果,为氟化氨银应用于临床龋病防治提供依据。方法检索知网、万方、维普、CBM数据库、PubMed、Web of Science、Cochrane library、Science Direct,收集自建库至2023年5月关于氟化氨银预防及抑制龋齿的随机对照试验文章。纳入的结局指标包括:龋失补牙面数、新发龋齿牙面数、静止龋牙面数。本Meta分析运用satat17.0软件进行数据分析。结果从数据库中共检索出1532篇相关文献,并根据纳入及排除标准,最终纳入10篇文献。Meta分析结果显示,应用氟化氨银和氟化钠相比,新发龋齿牙面数无显著性差异(SMD=-0.133,95%CI=-0.28~0.01,P=0.503);应用氟化氨银后静止龋牙面数较多(SMD=0.626,95%CI=0.42~0.83,P=0.915)。应用氟化氨银和安慰剂相比,龋失补牙面数无显著性差异(SMD=-0.519,95%CI=-1.18~0.14,P=0);应用氟化氨银后新发龋齿牙面数较少(SMD=-0.448,95%CI=-0.62~-0.28,P=0.085);应用氟化氨银后静止龋牙面数较多(SMD=0,95%CI=0.62~0.86,P=0.34)。结论应用氟化氨银有利于预防及抑制龋齿,建议在临床上广泛应用。

Objective To comprehensively and systematically evaluate the clinical effect of Silver diamine fluoride(SDF)on caries The method of tooth prevention and control selection provides scientific basis.Methods Search CNKI,Wanfang,VIP,CBM,PubMed,Web of Science,Cochrane Library,Science Direct,Randomized controlled trial articles on the prevention and inhibition of dental caries with silver ammonium fluoride were collected from self-built database until in May 2023.The outcome indexes included:the number of lost dental fillings,the number of newly developed caries,and the number of inactive caries.satatl7.0 was used for data analysis in this meta-analysis.Results A total of 1532 literatures were initially retrieved from the above database,and 10 literatures were included according to the inclusion and exclusion criteria.The results of meta-analysis showed that there was no significant difference in the number of tooth surfaces of new caries between silver diamine fluoride and sodium fluoride(SMD=-0.133,95%CI=-0.28~0.01,P=0.503).Silver ammonium fluoride was more abundant in the surface number of stationary caries(SMD=0.626,95%CI=0.42~0.83,P=0.915).Compared with blank control,there was no significant difference in the number of caries lost and filled teeth(SMD=-0.519,95%CI=-1.18~0.14,P=0).In terms of tooth surface number of new caries,silver ammonium fluoride was less(SMD=-0.448,95%CI=-0.62~-0.28,P=0.085).The amount of silver diamine fluoride was higher in the surface number of stationary caries(SMD=0,95%CI=0.62~0.86,P=0.34).Conclusion Silver diamine fluoride is beneficial to prevent and inhibit dental caries,and it is recommended to be widely used in clinic.