摘要
甲硫腺苷磷酸化酶(MTAP)是甲硫氨酸和嘌呤补救合成途径中的一个关键酶,与多胺代谢、腺嘌呤代谢和甲硫氨酸代谢密切相关。MTAP基因在恶性间皮瘤(MM)中频繁发生缺失,在恶性间皮瘤诊断与鉴别诊断中具有重要价值。同时,由于MTAP缺失引起代谢重编程,为MM带来了新的治疗策略。除此之外,MTAP基因也与MM的预后具有一定相关性,因此MTAP或可作为MM诊断、治疗和预后相关的重要生物标志物。
Methylthioadenosine phosphorylase(MTAP)is a rate-limiting enzyme in the methionine and purine salvage pathway,and is closely related to polyamine metabolism,adenine metabolism and methionine metabolism.MTAP is frequently deleted in malignant mesothelioma(MM)and plays an important role in the diagnosis and differential diagnosis of MM.At the same time,metabolic reprogramming caused by MTAP deletion creates new therapeutic strategies for MM.Besides,MTAP gene is also associated with the prognosis of MM,therefore MTAP is a significant biomarker for the diagnosis,treatment and prognosis of MM.
作者
金旭东
陈忠坚
毛伟敏
Jin Xudong;Chen Zhongjian;Mao Weimin(Postgraduate Training Base Alliance of Wenzhou Medical University(Zhejiang Cancer Hospital),Hangzhou 310022,China;Department of Thoracic Surgery,Zhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou 310022,China;Experimental Research Center,Zhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou 310022,China;Zhejiang Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology,Hangzhou 310022,China)
出处
《国际肿瘤学杂志》
CAS
2024年第2期99-104,共6页
Journal of International Oncology
基金
浙江省自然科学基金(LY23H010002)
浙江省医药卫生科技计划(2022KY622)
浙江省重点研发计划(2018C04009)。
关键词
甲硫腺苷磷酸化酶
恶性间皮瘤
诊断
鉴别
药物疗法
预后
Methylthioadenosine phosphorylase
Malignant mesothelioma
Diagnosis
differential
Drug therapy
Prognosis
