微针在经皮药物递送系统中的应用

The Application of Microneedles in Transdermal Drug Delivery Systems

作为经皮给药系统中新兴和高效递送形式的微针,可以定向突破角质层对药物吸收的限制。微针具有微创、无痛、高适应性和控释药物的优点,在生物医学经皮给药领域具有广阔的应用前景。综述主要总结近年来微针发展历程和研究进展,系统讨论了各种微针类型在应用时的优缺点,重点介绍微针制备技术在生物医学领域的研究进展,为微针的进一步开发利用提供相关参考。

Microneedles,as an emerging and efficient delivery system in transdermal drug delivery,can selectively penetrate the stratum corneum to overcome the limitations of drug absorption.They have such advantages as minimal invasiveness,painlessness,high compliance,and controlled release,with broad prospects in the field of biomedical transdermal drug delivery.This review briefly summarizes the development and research progress of microneedles in recent years,systematically discusses the advantages and disadvantages of various types of microneedles in medical application,and particularly introduces the research progress of microneedle preparation technology in the biomedical field,in order to provide some reference for the further development and application of microneedles.