The inverse association between eGFR and depression in patients with coronary artery disease: A cross-sectional study

Background The relationship between estimated glomerular filtration rate(e GFR)and depression in patients with coronary artery disease(CAD)remained unclear.Methods A total of 561 patients with CAD were selected from Department of Cardiology between October 2017 and February 2018 while their depression status was evaluated by Patient Health Questionnaire-9(PHQ-9).The e GFR levels were compared between patients with and without depression and the link between e GFR and depression in CAD patients was explored.Results Among 561CAD patients,63 patients(11.23%)were diagnosed with comorbid depression(PHQ-9≥10).The depression group presented significantly lower e GFR level than the non-depression group.In fully-adjusted multivariate analysis,higher e GFR level was proved to be a protective factor for depression in CAD patients,reducing a 22%risk of depression for every 10 m L/(min·1.73 m2)increase of e GFR level(OR:0.78,95%CI:0.66-0.93).Similar results were found in the stratified analyses of both e GFR quartiles and chronic kidney disease(CKD)stages(P for trend<0.05),while no significant differences were found among subgroups(P for interaction>0.05).A negative linear association was estimated between e GFR level and depression in CAD patients.Conclusions Our results suggested lower e GFR level in CAD patients with comorbid depression,displaying a negative linear correlation between e GFR and risk of depression in CAD patients.The findings implied that screening depression in CAD patients with decreased e GFR level or concomitant CKD should be highlighted in clinical practice.[S Chin J Cardiol 2024;25(1):1-10]