肺力咳胶囊对慢性阻塞性肺疾病急性加重期患者血气、血栓前状态及膈肌功能的影响

Effects of Feilike Capsules on blood gas,pre-thrombotic state,and diaphragm function in patients with acute exacerbation of COPD

目的 观察肺力咳胶囊对慢性阻塞性肺疾病(COPD)急性加重期患者血气、血栓前状态及膈肌功能的影响。方法 将我院收治的60例COPD急性加重期患者随机分为观察组与对照组各30例。对照组采用单一沙丁胺醇治疗,观察组在沙丁胺醇基础上加用肺力咳胶囊治疗。对比两组疗效及治疗前后中医症候(发热、气喘、咳嗽、咳痰),血气指标[血氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))、动脉血酸碱度(pH)],血栓前状态指标[D-二聚体(DD)、凝血酶抗凝血酶复合物(TAT)、纤维蛋白原(FIB)]及膈肌功能指标[呼气末膈肌厚度、吸气末膈肌厚度、膈肌增厚分数]。结果 治疗后,观察组总有效率高于对照组(P<0.05);两组发热、气喘、咳嗽、咳痰中医症候积分均明显低于治疗前,且观察组低于对照组(P<0.05);两组PaCO_(2)低于治疗前,PaO_(2)、pH均高于治疗前;且观察组PaCO_(2)低于对照组,PaO_(2)、pH高于对照组(P<0.05);两组DD、TAT、FIB水平均低于治疗前,且观察组低于对照组(P<0.05);两组呼气末膈肌厚度、吸气末膈肌厚度、膈肌增厚分数高于治疗前,且观察组高于对照组(P<0.05)。结论 肺力咳胶囊治疗急性加重期COPD患者,可改善血气指标、中医症候,缓解血栓前状态,促进膈肌功能提升,疗效显著,值得推广。

Objective To observe the effects of Feilike Capsules on blood gas,pre-thrombotic status and diaphragm function in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods Sixty patients with acute exacerbation of COPD were randomly divided into observation group and control group,with 30 cases in each group.Control group was treated with salbutamol,while observation group was treated with Feilike Capsules on the basis of control group.The efficacy TCM symptoms(fever,asthma,cough,expectoration)blood gas indicators(PaO_(2),PaCO_(2),pH),pre thrombotic state indicators[D-dimer(D-D),thrombin antithrombin complex(TAT),fibrinogen(FIB)],and diaphragm function indicators(end-expiratory diaphragm thickness,inspiratory diaphragm thickness,and diaphragm thickening fraction)before and after treatment of the two groups were compared.Results After treatment,the total effective rate of observation group was higher than that of control group(P<0.05);TCM syndrome scores of fever,asthma,cough,and phlegm in both groups were significantly lower than before treatment,and were lower in observation group than control group(P<0.05);PaCO_(2) levels in both groups were lower than before treatment,and were lower in observation group than control group;PaO_(2)and pH levels were higher than before treatment,and were higher in observation group than control group(P<0.05);DD,TAT,and FIB levels in both groups were lower than before treatment,and were lower in observation group than control group(P<0.05);the end expiratory diaphragm thickness,end inspiratory diaphragm thickness,and diaphragm thickening score of both groups were higher than before treatment,and were higher in observation group than control group(P<0.05).Conclusion Feilike Capsules can improve blood gas indicators,TCM symptoms,alleviate pre-thrombotic state,promote diaphragm function improvement,and has a significant therapeutic effect in treatment of acute exacerbation COPD,which is worth promoting.