抗片形吸虫病疫苗的研究进展

Research progress on vaccines against fascioliasis

片形吸虫病是由片形吸虫感染引起的人畜共患病,该病会引发机体的急慢性损伤,严重危害畜牧业发展,造成极大经济损失,目前用于治疗片形吸虫病的药物单一,且有耐药性产生,因此,急需更经济、可行的方式对家畜片形吸虫进行防治,以减少或避免人畜患病。疫苗是一种经济、有效的预防病原体感染的手段,有可能在片形吸虫病的预防中起到重要作用。本文就片形吸虫的抗原免疫应答机制及其疫苗研发现状作一综述,以期为片形吸虫病的防治提供科学参考和理论依据。

Fascioliasis is a zoonotic disease caused by fasciola infection,which will cause acute and chronic damage to the body,seriously endanger the development of animal husbandry,and cause great economic losses.At present,the drugs used to treat fascioliasis are single with drug resistance occurring.Therefore,there is an urgent need for a more economical and feasible way to control Fasciola in livestock to reduce or avoid diseases in humans and animals.Vaccine is an economical and effective means to prevent pathogen infection,which may play an important role in the prevention of fascioliasis.In this paper,the antigenic immune response mechanism of fasciola and its vaccine research are reviewed,so as to provide scientific reference and theoretical basis for the control of fascioliasis.