抗菌肽作为潜在的生物被膜抑制剂的研究进展

Research progress of antimicrobial peptides as potential biofilm inhibitors

细菌对抗菌药物的耐药性已成为人类健康的重大威胁,生物被膜的形成显著增加了细菌对抗菌药的耐药性和宿主的先天防御,成为微生物的主要毒力因子。抗菌肽(antimicrobial peptides,AMPs)具有广谱抗菌特性和抗生物被膜活性,已成为潜在的治疗药物。本文综述了生物被膜的形成、耐药性及其相关感染,特别关注了AMPs的抗生物被膜潜力,强调了其优点、对浮游菌的作用机制、抗生物被膜机制以及与抗菌药物协同作用的抗生物被膜活性等,以期为AMPs在临床生物被膜相关耐药菌感染中的应用提供参考。

Bacterial resistance to conventional therapies has become a major threat to human health,and the formation of biofilms has significantly increased the resistance of bacteria to antibiotics and the innate defense of the host to become the main virulence factor of microorganisms.Antimicrobial peptides(AMPs)have broad⁃spectrum antimicrobial properties and anti⁃biofilm activity,which have become potential therapeutic drugs.This review described biofilm formation,drug resistance and associated infections,with particular attention to the anti⁃biofilm potential of AMPs,highlighting their advantages,mechanism of action against planktonic bacteria,mechanism of anti⁃biofilm,and anti⁃biofilm activity in synergistic with antibiotics,so as to provide references for the application of AMPs in clinical biofilm⁃related drug⁃resistant bacterial infections.