脑CT灌注成像诊断抑郁症患者的价值

The value of cerebral CT perfusion imaging in the diagnosis of depression

目的探讨脑CT灌注成像诊断抑郁症患者的价值。方法将我院2021年3月至2022年12月期间收治的124例抑郁症患者为观察组,同期选取123例健康体检者作为对照组。所有受试者均进行脑CT灌注成像检查,比较两组颅脑各脑叶CT值、不同脑区脑血流量(rCBF)、平均通过时间(MTT)及曲线到达峰值时间(TTP)。结果两组左右顶、颞、枕叶增强扫描CT值对比差异无统计学意义(P>0.05),观察组左右额叶CT值低于对照组(P<0.05);左右顶、颞、枕叶rCBF对比差异无统计学意义(P>0.05),观察组左右额叶rCBF低于对照组(P<0.05);两组左右顶、颞、枕叶MTT对比差异无统计学意义(P>0.05),观察组左右额叶MTT长于对照组(P<0.05);两组左右顶、颞、枕叶TTP对比差异无统计学意义(P>0.05),观察组左右额叶TTP长于对照组(P<0.05)。结论脑CT灌注成像可准确检出抑郁症患者大脑额叶病变,以初步评估患者脑部病变异常,为疾病诊治疗提供一定依据。

Objective To explore the value of cerebral CT perfusion imaging in the diagnosis of depression.Methods 124 patients with depression admitted to our hospital from March 2021 to December 2022 were selected as the observation group,while 123 healthy individuals were selected as the control group during the same period.All subjects underwent brain CT perfusion imaging to compare the CT values of each lobe of the brain,cerebral blood flow(rCBF)in different brain re⁃gions,mean transit time(MTT),and curve to peak time(TTP)between the two groups.Results There was no significant difference between the two groups in CT values of left and right parietal,temporal,and occipital enhancement scans(P>0.05).The CT values of left and right frontal lobes in the observation group were lower than those in the control group(P<0.05);There was no significant difference in rCBF between the left and right parietal,temporal,and occipital lobes(P>0.05).The rCBF in the left and right frontal lobes in the observation group was lower than that in the control group(P<0.05);There was no significant difference in MTT between the two groups in the left and right parietal,temporal,and occip⁃ital lobes(P>0.05).The MTT in the observation group was longer in the left and right frontal lobes than in the control group(P<0.05);There was no statistically significant difference in TTP between the two groups in the left and right parie⁃tal,temporal,and occipital lobes(P>0.05).The TTP in the observation group was longer in the left and right frontal lobes than in the control group(P<0.05).Conclusion Brain CT perfusion imaging can accurately detect frontal lobe lesions in patients with depression,to preliminarily assess the abnormalities of brain lesions in patients,and provide a certain basis for disease diagnosis and treatment.