超声介入治疗妇科恶性肿瘤术后盆腔淋巴囊肿疗效及对性激素的影响研究

Study on effect of ultrasonic interventional treatment of pelvic lymphatic cyst after gynecological malignant tumor and its influence on sex hormones

目的探讨将超声介入疗法用于妇科恶性肿瘤术后盆腔淋巴囊肿的效果,并研究该疗法对性激素的影响。方法选取2020年1月—2021年6月河南省直第三人民医院收治的妇科恶性肿瘤患者,经手术治疗后并发盆腔淋巴囊肿者94例,以随机数字表法进行分组,对照组(n=47)以保守方案开展治疗,观察组(n=47)采用超声介入方案开展治疗,对比两组治疗后的疾病总疗效,治疗前后的性激素水平[雌二醇(E2)、黄体生成激素(LH)]与囊肿直径以及不良反应发生情况。结果观察组患者的治疗后总有效率为97.87%,高于对照组的82.98%(P<0.05);治疗前,对比两组E2、LH、P、FSH水平及囊肿直径并无明显差异(P>0.05),治疗后观察组E2、LH水平为(115.34±10.87)pmol/L与(8.44±0.43)U/L,低于对照组的(171.69±12.15)pmol/L与(9.64±0.51)U/L,且两组E2、LH水平均低于治疗前(均P<0.05);治疗前,对比两组囊肿直径无明显差异(P>0.05),治疗后观察组囊肿直径为(1.01±0.14)cm,低于对照组的(2.39±0.35)cm,组间对比差异有统计学意义(P<0.05);治疗后,观察组患者出现不良反应的占比2.13%,较比对照组的14.89%明显下降(P<0.05)。结论妇科恶性肿瘤术后并发盆腔淋巴囊肿患者的治疗,通过超声介入疗法可获得显著效果,可有效降低其性激素水平,缩小囊肿体积,且不易引发不良反应,疗效与安全性均值得信赖,值得积极推广应用。

Objective To explore the effect of ultrasound interventional treatment of pelvic lymphatic cyst after gynecological malignant tumor and its influence on sex hormones and ovarian function.Methods Ninety-four patients with gynecological malignant tumor who were treated in the Third People's Hospital of Henan Province from January 2020 to June 2021 and complicated with pelvic lymphocysts after surgical treatment were selected and divided into groups by random number table method.The control group(n=47)was treated with conservative program,and the observation group(n=47)was treated with ultrasonic intervention program.The total curative effect of the two groups after treatment,sex hormone levels[estradiol(E2),luteinizing hormone(LH)]before and after treatment,cyst diameter and the occurrence of adverse reactions were compared.Results The total effective rate of observation group was 97.87%,which was higher than that of control group(82.98%)(P<0.05).Before treatment,there were no significant differences in E2,LH,P,FSH levels and cyst diameter between the two groups(P>0.05).After treatment,E2 and LH levels in the observation group were(115.34±10.87)pmol/L and(8.44±0.43)U/L.The levels of(171.69±12.15)pmol/L and(9.64±0.51)U/L were lower than those of control group,and E2 and LH levels in both groups were lower than before treatment(P<0.05).Before treatment,there was no significant difference in cyst diameter between the two groups(P>0.05).After treatment,the cyst diameter in the observation group was(1.01±0.14)cm,which was lower than that in the control group(2.39±0.35)cm,and the difference between the two groups was statistically significant(P<0.05).After treatment,the proportion of adverse reactions in observation group was 2.13%,which was significantly decreased compared with 14.89%in control group(P<0.05).Conclusion For the treatment of patients with pelvic lymphocysts after surgery for gynecological malignant tumors,ultrasound interventional therapy can achieve significant effects,effectively reduce the level of sex hormones,reduce the volume of cysts,and is not easy to cause adverse reactions.The efficacy and safety are trustworthy,and it is worth actively promoting and applying.