肝癌肝移植后复发的文献计量和可视化分析

Bibliometrics and visualization analysis of hepatoma recurrence after liver transplantation

目的分析全球肝癌肝移植后复发领域的研究现状、热点和前沿。方法文献计量学研究。以Web of Science核心合集为数据来源,检索并收集1992年1月至2023年10月肝癌肝移植后复发相关文献,对发表国家/地区、发文期刊、发文作者和机构、引文、关键词等进行规范化处理和文献计量学分析,采用Citespace、VOSviewer和Bibliometric.com在线软件进行统计、突现以及共现聚类的可视化分析。结果共检索到文献4936篇,经严格筛选后,1189篇文献纳入最终分析。1992年至2021年,全球肝癌肝移植后复发领域发文量呈逐年上升趋势,2021年全球范围内和我国发文量均达到高峰(103篇和32篇);中国在该领域的发文量最多(308篇),且与美国、韩国、日本、加拿大等国家合作较为密切;Liver Transplantation是刊载该领域文献最多的期刊(113篇);浙江大学是该领域发文量最多的第一作者单位(74篇),浙江大学郑树森院士是该领域发文量最多的学者(76篇)。引文突现检测发现,意大利学者Mazzafeno于2009年发表在The Lancet Oncology的Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria:a retrospective,exploratory analysis一文的突现强度最高(36.98)。关键词突现检测显示,alpha fetoprotein(甲胎蛋白)、model(模型)、validation(验证)、sorafenib(索拉非尼)和risk(风险)是5个目前仍在突现的关键词。关键词共现聚类分析共得到5个聚类,分别为肝癌肝移植后复发药物治疗方案、肝癌肝移植受者选择标准、预后影响因素、复发预测模型的建立与验证和肝癌局部治疗方法。结论肝癌肝移植后复发领域在过去30余年间发展迅速,以浙江大学和郑树森院士为代表的我国学者做出了突出贡献。随着学科发展的不断成熟,肝癌肝移植后复发领域的研究热点逐渐从各中心肝癌肝移植经验和受者选择标准的制定,转变为移植后早期复发风险的预测和药物治疗方案的选择。

Objective This study aimed to evaluate the global research landscape,identify trends,and determine hotspots concerning hepatoma recurrence post-liver transplantation.Methods We conducted a bibliometric analysis usinga systematic search was conducted in the Web of Science Core Collection database from Jan.1992 to Oct.2023 to identify relevant articles on hepatoma recurrence after liver transplantation.Articles were selected based on inclusion and exclusion criteria and analyzed for publication trends by country/region,journal,author,institution,citation,and keyword.Visualization tools such as Citespace,VOSviewer,and Bibliometric.com were utilized for statistical analysis,identification of emerging trends,and clustering of keyword co-occurrence.Results Out of 4,936 articles retrieved,1,189 were included in the final analysis.There was a notable increase in publications on hepatoma recurrence following liver transplantation from 1992 to 2021,peaking in 2021 both globally(n=103)and nationally(n=32).China has the largest number of publications in this field(n=308),maintaining significant collaboration with the United States,South Korea,Japan,Canada.'Liver Transplantation’journal had the highest number of publications(n=113).Zhejiang University was the leading institution(n=74),with Academician Zheng Shusen being the most prolific scholar(n=76 publications).Citation emergence detection found that Italian scholar Mazzaferro's Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria:a retrospective,exploratory analysis published on The Lancet Oncology in 2009 had the highest burst strength(36.98).Five bursting keywords were identified:alpha fetoprotein,model,validation,sorafenib,and risk.Cluster analysis of keyword co-occurrence revealed five primary research themes:the medication for hepatocellular carcinoma recurrence after liver transplantation,recipient selection criteria,prognostic factors,development and validation of recurrence prediction model,and local treatments for hepatocellular carcinoma.Conclusions The study underscores rapid advancements in the research on hepatocellular carcinoma recurrence post-liver transplantation over the past three decades,with significant contributions from Chinese scholars,particularly from Zhejiang University and Academician Zheng Shusen.The evolving research hotspots have shifted from transplantation experiences and recipient selection criteria to early post-transplant recurrence risk prediction and therapeutic strategy development.