血清lncRNA HULC、lncRNA HOTAIR水平与前列腺癌肿瘤血管生成及根治术后短期预后的关联性探讨

Relationship of serum lncRNA HULC and lncRNA HOTAIR levels with tumor angiogenesis and short-term prognosis after radical resection of prostate cancer

目的:探讨血清长链非编码RNA(lncRNA)HULC、lncRNA HOTAIR水平与前列腺癌肿瘤血管生成及根治术后短期预后的关联性。方法:选取本院2019年5月至2021年1月接受的98例前列腺癌患者作为实验组,并选取同期97例良性前列腺增生患者作为对照组,比较两组患者的血清lncRNA HULC、lncRNA HOTAIR水平及临床资料[年龄、基础病史、前列腺体积、微血管密度(MVD)等];对比实验组患者不同病理特征的血清lncRNA HULC、lncRNA HOTAIR水平;对实验组患者展开为期1年的随访,并按照随访结果将患者分为肿瘤无进展组(70例)和进展组(28例),对比两组患者的临床资料,采用多元logistic回归分析前列腺癌患者根治术后短期进展的独立危险影响因素。结果:实验组的血清lncRNA HULC和lncRNA HOTAIR水平均高于对照组(均P<0.05);TNM分期Ⅱ~Ⅲ期、中高分化程度、存在淋巴结转移以及高微血管密度(MVD)患者的血清lncRNA HULC、lncRNA HOTAIR水平均高于TNM分期Ⅰ期、低分化程度、不存在淋巴结转移以及低MVD患者(均P<0.05);与肿瘤无进展组患者相比,肿瘤进展组患者的TNM分期Ⅱ~Ⅲ期、中高分化程度、存在淋巴结转移、高MVD占比及血清lncRNA HULC、lncRNA HOTAIR水平更高(均P<0.05);TNM分期、分化程度、淋巴结转移、MVD、血清lncRNA HULC和lncRNA HOTAIR水平均是引起前列腺癌患者根治术后短期进展的独立危险因素(均P<0.05)。结论:lncRNA HULC、lncRNA HOTAIR与前列腺癌肿瘤血管生成相关,同时是影响患者根治术后短期预后的独立危险因素。

Objective To investigate the relationship of serum long noncoding RNA(lncRNA)HULC and IncRNA HOTAIR levels with tumor angiogenesis and short-term prognosis after radical resection of prostate cancer.Methods Ninety-eight patients with prostate cancer in our hospital from May 2019 to January 2021 were enrolled as experimental group,meantime,another 97 patients with benign prostatic hyperplasia in our hospital were enrolled as control group.Serum lncRNA HULC,IncRNA HOTAIR and clinical data including age,underlying disease,prostate volume,microvessel density(MVD)were compared between two groups.Serum IncRNA HULC and IncRNA HOTAIR levels were compared in the experimental group with different pathological characteristics.Patients in the experimental group were followed up for 1 year,and according to the follow-up results,the patients were divided into tumor progression-free group(70 cases)and progressive group(28 cases).The clinical data of the two groups were compared,and the independent risk factors influencing the shortterm progression of prostate cancer patients after radical surgery were analyzed by multiple logistic regression.Results Serum IncRNA HULC and IncRNA HOTAIR levels were significantly higher in experimental group than in control group(all P<0.05).Serum IncRNA HULC and IncRNA HOTAIR levels in patients with TNM stageⅡtoⅢ,intermediate and high differentiation,lymph node metastasis and high MVD were higher than those in patients with TNM stageⅠ,low differentiation and no lymph node metastasis and low MVD(all P<0.05).Compared with the non-progression group,the TNM stageⅡtoⅢ,intermediate and high differentiation,lymph node metastasis,high MVD ratio and serum IncRNA HULC and IncRNA HOTAIR levels were higher in the tumor progression group(all P<0.05).TNM stage,differentiation degree,lymph node metastasis,MVD,serum IncRNA HULC and IncRNA HOTAIR were all independent risk factors for short-term progression of prostate cancer after radical surgery(all P<0.05).Results The lncRNA HULC and IncRNA HOTAIR are associated with tumor angiogenesis in patients with prostate cancer and the two are also independent risk factors affecting short-term prognosis after radical surgery.