炎症营养指标评估胃癌新辅助化疗疗效及预后研究进展

Research progress of inflammatory and nutritional indicators in evaluating the efficacy and prognosis of neoadjuvant chemotherapy for gastric cancer

新辅助化疗已成为局部进展期胃癌综合治疗的重要内容,对新辅助化疗的疗效及预后评估尤为重要。炎症营养状况不仅与胃癌的发生和进展相关,还与新辅助化疗的疗效及预后密切相关。炎症营养指标的获取简单快捷,其在新辅助治疗前后的水平及变化情况与肿瘤退缩分级、无病生存期、总生存期等密切相关。基于炎症营养指标等临床病理特征的新辅助化疗后胃癌病人预后预测模型也表现出良好的效能。外周血炎症营养指标有望成为评估胃癌新辅助化疗疗效及预后的可靠指标,具有广阔的临床应用前景。

Neoadjuvant chemotherapy has become an essential component of the comprehensive treatment of locally advanced gastric cancer,and it is particularly important to evaluate the efficacy and prognosis of neoadjuvant chemotherapy.Inflammatory and nutritional status is not only related to the occurrence and progression of gastric cancer but also closely related to the efficacy and prognosis of neoadjuvant chemotherapy.The acquisition of inflammatory and nutritional indicators is simple and rapid,and the value of inflammatory and nutritional indicators and their changes before and after neoadjuvant therapy are closely related to tumor regression grade,disease-free survival,overall survival,and so on.The prediction model of prognosis of patients with gastric cancer after neoadjuvant chemotherapy based on inflammatory and nutritional indicators and other clinical and pathological characteristics also showed brilliant performance.The peripheral blood inflammatory and nutritional indicators are expected to become reliable indexes to evaluate the efficacy and prognosis of neoadjuvant chemotherapy for gastric cancer and have a broad clinical application prospect.