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Vascularization ability of glioma stem cells in different three-dimensional microenvironments 被引量:1

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摘要 Glioblastoma(GBM)is among the most common and aggressive adult central nervous system tumors.One prominent charac-teristic of GBM is the presence of abnormal microvessels.A significant correlation between angiogenesis and prognosis has been observed.Accurately reconstructing this neovascula-rization and tumor microenvironment through personalized in vitro disease models presents a significant challenge.However,it is crucial to develop new anti-angiogenic therapies for GBM.In this study,3D bioprinted glioma stem cell(GSC)-laden hydrogel scaffolds,hybrid Gsc hydrogels and ceil-free hydrogel scaffolds were manufactured to investigate the vas-cularization ability of GsCs in varying 3D microenvironments.
出处 《Regenerative Biomaterials》 SCIE EI CSCD 2024年第1期34-43,共10页 再生生物材料(英文版)
基金 supported by the Anhui Provincial Natural Science Foundation(2308085MH279) the Fundamental Research Funds for the Central Universities(WK9110000156) Key Research and Development Program of Anhui Province(202104j07020025) 2021 Anhui Provincial Quality Engineering Project for Higher Education Institutions(2021jyxm1778).
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