阿尔茨海默病与运动障碍

Alzheimer's disease and motor dysfunction

阿尔茨海默病(AD)是最常见的认知障碍类型,除常见的认知功能障碍、精神行为症状和日常生活活动能力受损外,越来越多的研究证据表明,AD患者在疾病早期甚至前驱期和临床前期即表现出不同部位和类型的运动功能障碍,包括眼球运动、上肢运动、步态和平衡功能障碍。本文论述AD患者运动障碍的表现及其与认知障碍和生物标志物的关系,以期帮助AD的早期筛查、诊断和干预。

Alzheimer's disease(AD)is the most prevalent form of cognitive impairment.Alongside common cognitive deficits,neuropsychiatric symptoms,and compromised daily activities,a growing body of research indicates that AD patients exhibit various forms of motor dysfunction,such as eye movement,upper limb movement,and gait and balance issues,even in the early stages,including the prodromal and preclinical phases of AD.This article introduced the presentation of motor dysfunction,its correlation with cognitive impairment and AD biomarkers,with the aim of aiding in the early detection,diagnosis,and treatment of AD.