N6-腺苷酸甲基化修饰在呼吸系统疾病发生发展中作用的研究进展

Research progress on the role of N6-methyladenosine methylation in the pathogenesis and development of respiratory diseases

N6-腺苷酸甲基化(m6A)是真核生物mRNA最常见的转录后修饰行为之一。m6A修饰可加速mRNA的代谢和翻译,在细胞分化、胚胎发育和免疫应答等过程中发挥重要作用。作为一种可逆的表观遗传修饰,m6A修饰在许多生理和病理过程中发挥着重要作用。m6A修饰与呼吸系统疾病的发生发展密切相关,m6A修饰调控因子可能成为调控呼吸系统疾病的潜在作用靶点。本文对m6A修饰在肺癌、急性肺损伤(ALI)、哮喘、肺纤维化、慢性阻塞性肺疾病(COPD)等呼吸系统疾病发生发展中的作用进行了综述,旨在为呼吸系统疾病的发病机制及药物作用靶点研究提供参考。

N6-methyladenosine(m6A)is one of the most common post-transcriptional modifications of eukaryotic mRNA.The m6A modification accelerates mRNA metabolism and translation,and plays an important role in cell differentiation,embryonic development and stress response.As a reversible epigenetic modification,m6A modification plays an important role in many physiological and pathological processes.The m6A modification is closely related to the occurrence and progression of respiratory diseases,and the m6A modification regulatory factor may be a potential target for regulating respiratory diseases.This article reviews the role of m6A modification in the development of respiratory diseases such as lung cancer,acute lung injury(ALI),asthma,pulmonary fibrosis,and chronic obstructive pulmonary disease(COPD).The purpose of m6A modification is to provide a reference for the pathogenesis of respiratory diseases and the study of targets.