Notoamide E的全合成

Total synthesis of notoamide E

目的对分离于海洋真菌的notoamide E进行全合成研究。方法通过吲哚C-6位的高选择性溴代反应、Miyaura硼化反应、oxa-[3+3]环加成等关键反应,完成目标化合物的合成。结果以廉价易得的L-色氨酸甲酯盐酸盐为原料,经9步反应,以9.5%的总产率实现notoamide E的全合成。

Objective Total synthesis of notoamide E isolated from marine fungi.Methods The target product was synthesized by using some key steps such as selective bromination of indole at C-6,Miyaura boration,oxa-[3+3]cycloaddition reaction and so on.Results Total synthesis of notoamide E was achieved from cheap methyl L-tryptophanate hydrochloride in 9 steps(9.5%total yield).