一氧化氮与哺乳动物卵母细胞成熟

Nitric Oxide and Maturation of Mammalian Oocytes

一氧化氮(NO)是生物机体内第一种被发现的气体分子信号传导介质,不同组织中均可生成NO,并在机体内发挥相应的调节作用。哺乳动物卵巢卵泡主要通过一氧化氮合酶(NOS)途径将L-精氨酸氧化为L-瓜氨酸,在此过程中产生等量的NO参与调节卵母细胞生长发育进程。卵母细胞的质量优劣是与辅助生殖中体外受精(IVF)率和辅助生殖技术(ART)成败相关的关键因素,而卵母细胞质量的优劣在很大程度上取决于其所在卵泡微环境内的减数分裂进程与状态。论文从卵巢卵泡中NO的来源和作用机制出发,介绍NO与卵母细胞成熟进程的关系,通过阐明NO相关作用途径为医学临床改善卵母细胞质量的相关药物研发与治疗提供参考。

Nitric oxide(NO)is the first gas molecule identified as a signal mediator in the organism and can be produced in different tissues and plays a corresponding regulatory role in the biological organism.The mammalian ovarian follicle oxidizes L-arginine to L-citrulline mainly through the nitric oxide synthase(NOS)pathway,producing equal amounts of nitric oxide(NO)in the process,which allows it to participate in regulating the oocyte growth and development process.The quality of oocytes is a key factor in the success or failure of In Vitro Fertilisation(IVF)rates and Assisted Reproduction Techniques(ART)in assisted reproduction,and the quality of oocytes is largely dependent on the meiotic process and state of the follicular microenvironment in which they reside.This paper introduces the relationship between NO and oocyte maturation process from the source and mechanism of action of NO in ovarian follicles,and provides a reference for the development and treatment of drugs related to improving oocyte quality in medical clinics through NO-related pathways.