炎症负荷在预测老年上皮性卵巢癌患者预后中的价值

Value of Inflammatory Load in Predicting Prognosis of Elderly Patients with Epithelial Ovarian Cancer

目的探讨血液炎症负荷在预测老年上皮性卵巢癌患者预后中的价值。方法回顾性分析诊断为上皮性卵巢癌的老年(初诊年龄≥65岁)患者的临床资料和相关外周血参数。应用单变量和多变量Cox回归构建炎症相关的血液评分系统,使用Kaplan-Meier法进行生存分析,采用Cox风险比例回归分析确定独立预后影响因素,基于独立预后影响因素构建列线图模型并使用ROC曲线、C指数及校准曲线评价列线图模型。结果血液中炎症负荷高的患者预后更差(P=0.002)。与炎症负荷低组相比,炎症负荷高的上皮性卵巢癌患者临床分期更晚、腹水量更多(P<0.05)。Cox风险比例回归分析显示ACCI、CA125值、残留病灶和血液中炎症负荷是影响总生存期的独立预后因素(P<0.05)。结论血液中的炎症负荷是老年上皮性卵巢癌患者预后的生物标志物,通过对血液中炎症负荷评分可为卵巢癌患者的疗效监测和治疗干预提供帮助。

Objective To explore the value of blood inflammatory load in predicting overall survival of elderly patients with epithelial ovarian cancer(EOC).Methods Elderly patients with EOC were selected,and their clinical data and peripheral blood parameters were collected.We constructed an inflammation-related blood scoring system using univariate and multivariate Cox regression analysis.The Kaplan-Meier method was used for survival analysis.We used Cox proportional hazards analysis to identify the independent prognostic factors.A nomogram model was constructed based on independent prognostic factors,and the receiver operating characteristic curve,C-index,and calibration curve were used to evaluate the model.Results Patients with high blood inflammatory load had worse prognosis(P=0.002).Compared with the low inflammatory load group,patients with high inflammatory load had later clinical stages and larger ascites volume(P<0.05).Cox regression analysis showed that ACCI,CA125,residual lesions,and blood score were independent factors affecting overall survival(P<0.05).Conclusion The blood inflammatory load is the biomarker for the prognosis of elderly patients with EOC.Scoring the inflammatory load in the blood can assist in efficacy monitoring and treatment intervention of ovarian cancer patients.