佛手定眩汤加减联合尼麦角林片治疗短暂性脑缺血发作

Effect of modified Foshou Dingxuan decoction combined with nimagolin tablets in the treatment of patients with transient ischemic attack

目的观察佛手定眩汤加减联合尼麦角林片在短暂性脑缺血发作(TIA)患者中的治疗效果。方法选择短暂性脑缺血发作患者91例进行前瞻性随机对照研究,按随机数表法分为观察组(45例)与对照组(46例),研究过程中对照组1例因治疗依从性差剔除,最终2组各纳入45例。对照组服用尼麦角林片,观察组服用佛手定眩汤加减联合尼麦角林片,2组连续治疗4周。比较2组治疗4周后临床疗效,治疗前、治疗4周后2组血液流变学指标、氧化应激指标、血脂代谢指标,比较2组治疗期间不良反应发生情况。结果观察组总有效率(95.56%,43/45)高于对照组(80.00%,36/45)(P<0.05)。治疗4周后2组血浆黏度、全血高切黏度、全血低切黏度、红细胞压积低于治疗前,观察组低于对照组(P<0.05);2组丙二醛低于治疗前,谷胱甘肽、超氧化物歧化酶高于治疗前,观察组丙二醛低于对照组,谷胱甘肽、超氧化物歧化酶高于对照组(P<0.05);2组三酰甘油、总胆固醇、低密度脂蛋白胆固醇低于治疗前,观察组低于对照组(P<0.05)。2组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论佛手定眩汤加减联合尼麦角林片治疗短暂性脑缺血发作疗效显著,能改善患者血液流变学,减轻氧化应激反应,调节血脂代谢,用药安全性良好。

Objective To observe the therapeutic effect of modified Foshou Dingxuan decoction combined with nimagolin tablets in patients with transient ischemic attack(TIA).Methods A prospective randomized controlled study was conducted on 91 patients with transient ischemic attack,who were divided into an observation group(45 cases)and a control group(46 cases)using a random number table method.During the study,one patient in the control group was excluded due to poor treatment compliance,and 45 cases were finally included in each of the two groups.The control group was given nimagolin tablets,while the observation group was given Foshou Dingxuan decoction combined with nimagolin tablets.Both groups were treated continuously for 4 weeks.The clinical efficacy of the two groups was compared after 4 weeks of treatment.The hemorheology indexes,oxidative stress indexes and lipid metabolism indexes were compared between the two groups before and after 4 weeks of treatment.The incidence of adverse reactions during the treatment period was compared between the two groups.Results The total effective rate of the observation group(95.56%,43/45)was higher than that of the control group(80.00%,36/45)(P<0.05).After 4 weeks of treatment,the plasma viscosity,whole blood high tangential viscosity,whole blood low tangential viscosity and hematocrit of both groups were lower than before treatment,and the observation group was lower than the control group(P<0.05).Malondialdehyde was lower than before treatment in both groups,while glutathione and superoxide dismutase were higher than before treatment,and malondialdehyde in the observation group was lower than the control group,while glutathione and superoxide dismutase were higher than the control group(P<0.05).Triglyceride,total cholesterol and low density lipoprotein cholesterol in the two groups were lower than before treatment,and the observation group was lower than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of modified Foshou Dingxuan decoction and nimagolin tablets has a significant therapeutic effect in the treatment of transient ischemic attack,which can improve patients'hemorheology,alleviate oxidative stress reactions,regulate blood lipid metabolism,and have a good medication safety.