非惊厥性癫痫持续状态的相关因素研究

Study on Related Factors of Non-convulsive Status Epilepticus

目的探讨非惊厥性癫痫(Nonconvulsive Seizure,NCS)持续发病的影响因素。方法回顾性选取2018年1月—2021年12月定西市第二人民医院神经内科收治的64例患者的临床资料,根据非惊厥性癫痫是否持续发作进行分组,分为持续组(n=32)、非持续组(n=32)。评价两组睡眠质量,测定两组血同型半胱氨酸(Homocysteine,Hcy)水平,利用Logistic回归分析,分析NCS持续发病的危险因素。结果持续组的睡眠障碍(Sleep Disorder,SD)、高同型半胱氨酸血症(Hyperhomocysteinemia,HHcy)相较于非持续组更高,差异有统计学意义(P均<0.05)。基于多因素Logistic回归分析,SD对NCS的OR值为2.275,HHcy对NCS的OR值为3.154,差异有统计学意义(P均<0.05)。结论SD和HHcy可能对NCS的发病具有促进作用,是其独立危险因素。临床诊疗NCS时,有必要关注患者的睡眠状况并监测Hcy水平。

Objective To investigate the factors affecting the persistent onset of non convulsive seizure(NCS).Methods Clinical data of 64 patients admitted to the Department of Neurology of Dingxi Second People's Hospital from January 2018 to December 2021 were selected as the study objects and divided into continuous group(n=32)and non-continuous group(n=32)according to whether non-convulsive epilepsy lasted.The sleep quality of the two groups was evaluated,and the blood homocysteine(Hcy)level of the two groups was determined.Logistic regression analysis was used to analyze the risk factors for the persistent onset of NCS.Results The sleep disorder(SD)and hyperhomocysteinemia(HHcy)in the continuous group were higher than those in the non-continuous group,and the differences were statistically significant(both P<0.05).Based on multivariate Logistic regression analysis,the OR value of SD for NCS was 2.275 and the OR value of HHcy for NCS was 3.154,and the differences were statistically significant(both P<0.05).Conclusion SD and HHcy may promote the development of NCS and are independent risk factors.In clinical diagnosis and treatment of NCS,it is necessary to pay attention to the sleep status of patients,monitor the Hcy level.