孟鲁司特钠联合丙卡特罗治疗慢性咳嗽患儿的疗效及其对血清IgE和EOS水平的影响

Effect of Montelukast Sodium Combined with Procaterol on Serum IgE and EOS Levels in Children with Chronic Cough

目的探究丙卡特罗联合孟鲁司特钠治疗慢性咳嗽患儿的疗效及对血清免疫球蛋白E和嗜酸性粒细胞水平的影响。方法简单随机选取2021年11月—2022年12月南安市总医院英都分院收治的100例慢性咳嗽患儿作为研究对象,以信封法随机分为对照组和研究组,各50例。对照组给予丙卡特罗治疗,研究组给予丙卡特罗联合孟鲁司特钠治疗。对比两组症状体征指标评分、血清免疫球蛋白E及嗜酸性粒细胞水平、炎症因子水平及不良反应发生情况。结果治疗后,研究组慢性咳嗽患儿临床症状体征指标评分低于对照组,差异有统计学意义(P<0.05)。研究组血清免疫球蛋白E及嗜酸性粒细胞水平均低于对照组,差异有统计学意义(P均<0.05)。研究组的肿瘤坏死因子α、白细胞介素-6、C反应蛋白水平均低于对照组,差异有统计学意义(P均<0.05)。研究组不良反应发生率为6.00%,与对照组的16.00%对比,差异无统计学意义(χ^(2)=2.554,P>0.05)。结论临床上慢性咳嗽患儿使用孟鲁司特钠和丙卡特罗两种药物治疗,可缓解病症,血清免疫球蛋白E及嗜酸性粒细胞水平明显下降,炎症反应得到显著改善,安全性较佳。

Objective To explore the efficacy of procaterol combined with montelukast sodium in the treatment of children with chronic cough and the effects of serum immunoglobulin E and eosinophil levels.Methods A total of 100 children with chronic cough admitted to Yingdu Branch of Nan'an General Hospital from November 2021 to December 2022 were simple randomly selected as the study objects.They were randomly divided into control group and study group by envelope method,with 50 cases each.The control group was treated with procatterol and the study group was treated with Montelukast sodium combined with procatterol.Symptom and sign index scores,serum immunoglobulin E and eosinophil levels,inflammatory factor levels and adverse reactions occurrence were compared between the two groups.Results After treatment,the score of clinical symptoms and signs in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).The levels of serum immunoglobulin E and eosinophils in the study group were lower than those in the control group,and the differences were statistically significant(both P<0.05).The levels of tumor necrosis factor α,interleukin-6 and C-reactive protein in study group were lower than those in control group,and the differences were statistically significant(all P<0.05).The incidence of adverse reactions in the study group was 6.00%,but there was no statistically significant difference compared with the control group(16.00%)(χ^(2)=2.554,P>0.05).Conclusion Montelukast sodium and procatterol are used to treat children with chronic cough in clinical practice.It can be concluded that the two drugs can alleviate symptoms,serum immunoglobulin E and eosinophilic granulocyte levels are significantly decreased,inflammatory response is significantly improved,and the safety is better.