低分子肝素联合胰岛素治疗高脂血症性胰腺炎的临床疗效及对血清炎症介质的影响

Clinical Efficacy of Low Molecular Weight Heparin Combined with Insulin in the Treatment of Hyperlipidemic Pancreatitis and Its Effect on Serum Inflammatory Mediators

目的探究低分子肝素与胰岛素联合治疗高脂血症性胰腺炎的临床疗效。方法方便选取山东省济南市章丘区中医医院于2021年8月—2023年10月收治的86例高脂血症性胰腺炎患者为研究对象,采用密闭信封法分为对照组(n=43)和研究组(n=43)。所有患者均进行常规治疗,对照组在此基础上使用胰岛素注射液,研究组在对照组基础上使用低分子肝素钙,两组均治疗1周。对比两组患者临床疗效、不良反应发生率、血脂水平、血淀粉酶水平、血清炎症介质水平。结果研究组治疗有效率高于对照组,差异有统计学意义(P<0.05);治疗后,研究组血脂、血淀粉酶、炎症因子水平低于对照组,差异有统计学意义(P均<0.05);两组患者不良反应发生率对比,差异无统计学意义(P>0.05)。结论高脂血症性胰腺炎患者应用低分子肝素联合胰岛素治疗,能够提高治疗有效率,并改善炎症反应,从而降低血脂、血淀粉酶水平,且不会增加不良反应发生率。

Objective To explore the clinical efficacy of low molecular weight heparin combined with insulin in the treatment of hyperlipidemic pancreatitis.Methods 86 patients with hyperlipidemic pancreatitis admitted to Zhangqiu District Hospital of Traditional Chinese Medicine of Jinan City,Shandong Province from August 2021 to October 2023 were conveniently selected as the study objects,and were divided into control group(n=43)and research group(n=43)by sealed envelope method.All patients received conventional treatment,the control group received insulin injection on the basis of this,the study group received low molecular weight heparin calcium on the basis of the control group,and both groups were treated for 1 week.The clinical efficacy,incidence of adverse reactions,blood lipid level,serum amylase level and serum inflammatory mediators were compared between the two groups.Results The effective rate of the research group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of blood lipids,amylase and inflammatory factors in the research group were lower than those in the control group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In patients with hyperlipidemic pancreatitis,low molecular weight heparin combined with insulin can improve the therapeutic effectiveness and improve the inflammatory response,thus reducing the level of blood lipid and blood amylase without increasing the risk of adverse reactions.