低分子肝素联合阿司匹林治疗妊娠期高血压疾病对患者凝血功能、子宫动脉血流及妊娠结局的影响

Effects of low molecular weight heparin combined with aspirin on coagulation function,uterine artery flow and pregnancy outcome in patients with hypertensive diseases during pregnancy

目的探讨低分子肝素联合阿司匹林治疗妊娠期高血压疾病对患者凝血功能、子宫动脉血流及妊娠结局的影响。方法选取60例妊娠期高血压疾病患者,随机分为研究组和对照组,每组30例。对照组采用低分子肝素治疗,研究组采用低分子肝素联合阿司匹林治疗。比较两组患者的凝血功能、子宫血脉流动指标及不良妊娠结局发生率。结果治疗后,研究组D-2聚体水平低于对照组(P<0.05)。治疗后,研究组阻力指数、髂外动脉侧的搏动指数、脐动脉舒张压血流速度高低比值均高于对照组(P<0.05)。研究组不良妊娠结局发生率为6.67%,显著低于对照组的26.67%(P<0.05)。结论采用低分子肝素联合阿司匹林治疗妊娠期高血压疾病患者,能有效降低其D-2聚体水平,平稳患者子宫动脉血流,改善其妊娠结局。

Objective To investigate the effects of low molecular weight heparin combined with aspirin on coagulation function,uterine artery flow and pregnancy outcome in patients with hypertensive diseases during pregnancy.Methods 60 patients with hypertensive diseases during pregnancy were randomly divided into a study group and a control group,with 30 cases in each group.The control group was treated with low molecular weight heparin,and the study group was treated with low molecular weight heparin combined with aspirin.The coagulation function,uterine blood flow indexes and the incidence of adverse pregnancy outcome were compared between the two groups.Results After treatment,the level of D-2 polymer in the study group was lower than that in the control group(P<0.05).After treatment,the resistance index,the pulse index of external iliac artery and the umbilical arterial S/D ratio in the study group were higher than those in the control group(P<0.05).The incidence of adverse pregnancy outcome in the study group was 6.67%,which was significantly lower than 26.67% in the control group(P<0.05).Conclusion Low molecular weight heparin combined with aspirin in the treatment of hypertensive diseases during pregnancy can effectively reduce the D-2 polymer level,stabilize the uterine artery blood flow and improve the pregnancy outcome.