腹腔镜子宫肌瘤剥除术联合促性腺激素释放激素治疗子宫肌瘤的临床效果

Clinical efficacy of laparoscopic myomectomy combined with gonadotropin-releasing hormone therapy for uterine fibroids

目的探讨腹腔镜子宫肌瘤剥除术联合促性腺激素释放激素治疗子宫肌瘤的临床效果。方法选取52例子宫肌瘤患者为研究对象,采用单双数字抽签法分为两组,各26例。参比组采用腹腔镜子宫肌瘤剥除术治疗,联合组采用腹腔镜子宫肌瘤剥除术联合促性腺激素释放激素治疗,比较两组的性激素水平、手术指标、并发症发生率、复发率与术后24h疼痛评分。结果联合组卵泡刺激素、黄体生成素水平高于参比组,雌二醇水平低于参比组(P<0.05);联合组手术时间、排气时间、住院时间短于参比组,术中出血量少于参比组(P<0.05);联合组术后并发症发生率、复发率为3.85%、0,低于参比组的23.08%、15.33%(P<0.05);联合组术后24h疼痛评分低于参比组(P<0.05)。结论腹腔镜子宫肌瘤剥除术联合促性腺激素释放激素治疗子宫肌瘤,疗效显著,能明显改善患者的性激素水平,降低并发症及复发率,值得推广。

Objective To Explore the clinical efficacy of laparoscopic myomectomy combined with gonadotropinreleasing hormone treatment for uterine fibroids.Methods A total of 52 patients with uterine fibroids were selected as the research subjects,and were divided into two groups using a single and double digit lottery method,with 26 cases in each group.The reference group was treated with laparoscopic myomectomy,while the combination group was treated with laparoscopic myomectomy combined with gonadotropin-releasing hormone therapy.The sex hormone levels,surgical indicators,incidence of complications,recurrence rate,and postoperative 24-hour pain scores were compared between the two groups.Results The levels of follicle stimulating hormone and luteinizing hormone in the combination group were higher than those in the control group,while the levels of estradiol were lower than those in the control group(P<0.05),.The surgery time,exhaust time,and hospitalization time of the combined group were shorter than those of the control group,and the intraoperative bleeding was less than that of the control group(P<0.05).The incidence and recurrence rates of postoperative complications in the combination group were 3.85%and 0,which were lower than the control group's 23.08%and 15.33%(P<0.05).The pain score at 24 hours after surgery in the combination group was lower than that in the control group(P<0.05).Conclusion Laparoscopic myomectomy combined with gonadotropin-releasing hormone therapy has a significant therapeutic effect on uterine fibroids.It can significantly improve the patient's sex hormone levels,reduce complications and recurrence rates,and is worth promoting.