多囊卵巢综合征患者血清炎症标志物与脂代谢异常的关系分析

Relationship between peripheral blood inflammatory markers and abnormal lipid metabolism in patients with polycystic ovary syndrome

目的探讨外周血炎症标志物与多囊卵巢综合征(PCOS)患者合并脂代谢异常的相关性。方法纳入PCOS患者191例,其中血脂正常组95例,血脂异常组96例。比较两组血清炎症标志物等相关指标,采用Pearson相关性分析炎症标志物与脂代谢的相关性。结果血脂异常组的血清炎症标志物水平均高于正常组(P<0.05);中性粒细胞与淋巴细胞比值(NLR)、衍生中性粒细胞与淋巴细胞比值(dNLR)、系统免疫炎症指数(SII)与PCOS患者发生脂代谢异常呈正相关(P<0.05),血小板与淋巴细胞比值(PLR)与其无相关性(P>0.05)。结论NLR、dNLR、SII与PCOS患者发生脂代谢异常相关。

Objective To explore the relationship between peripheral blood inflammatory markers and abnormal lipid metabolism in patients with polycystic ovary syndrome(PCos).Methods A total of 191 patients with PCoS were included,including 95 patients with normal lipids and 96 patients with abnormal lipids.Serum inflammatory markers and other related indicators were compared between the two groups,and Pearson correlation was used to analyze the correlation between inflammatory markers and lipid metabolism.Results The levels of serum inflammatory markers in dyslipidemia group were higher than those in normal group(P<0.05).The ratio of neutrophil to lymphocyte(NLR),derived neutrophil to lymphocyte(dNLR),and systemic immunoinflammatory index(SII)were positively correlated with abnormal lipid metabolism in PCOS patients(P<0.05),but the ratio of platelet to lymphocyte(PLR)was not correlated with PCOS patients(P>0.05).Conclusion NLR,dNLR and SII were associated with abnormal lipid metabolism in PCOS patients.